| Literature DB >> 22286022 |
Abstract
Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis.Entities:
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Year: 2012 PMID： 22286022 DOI： 10.1016/j.vph.2012.01.002
Source DB: PubMed Journal: Vascul Pharmacol ISSN： 1537-1891 Impact factor: 5.773