BACKGROUND: Most patients with dementia also suffer from behavioral and psychological symptoms of dementia, for which there is no Food and Drug Administration-approved treatment. OBJECTIVES: To determine whether the Food and Drug Administration's black box warning in April 2005 has led to a decline in prescriptions of atypical antipsychotics for behavioral and psychological symptoms of dementia, as well as whether prescriptions for other psychotropic drugs, including antidepressants, anxiolytics, and antiepileptics, as substitutes, have increased. METHODS: Data on outpatient visits by elderly dementia patients were obtained from two large national surveys from 2003 to 2008. Any psychotropic drug mentions were identified. Percentage utilization statistics were calculated. RESULTS: The percentage of visits mentioning an atypical antipsychotic decreased from 12.5% prewarning to 11.5% postwarning. Postwarning, 34.4% of patients were taking none of the study medications, as opposed to 26.1% prewarning. CONCLUSIONS: After the warning, there was a small decline in the use of atypical antipsychotics and no evidence of substitution of other psychotropic medications.
BACKGROUND: Most patients with dementia also suffer from behavioral and psychological symptoms of dementia, for which there is no Food and Drug Administration-approved treatment. OBJECTIVES: To determine whether the Food and Drug Administration's black box warning in April 2005 has led to a decline in prescriptions of atypical antipsychotics for behavioral and psychological symptoms of dementia, as well as whether prescriptions for other psychotropic drugs, including antidepressants, anxiolytics, and antiepileptics, as substitutes, have increased. METHODS: Data on outpatient visits by elderly dementiapatients were obtained from two large national surveys from 2003 to 2008. Any psychotropic drug mentions were identified. Percentage utilization statistics were calculated. RESULTS: The percentage of visits mentioning an atypical antipsychotic decreased from 12.5% prewarning to 11.5% postwarning. Postwarning, 34.4% of patients were taking none of the study medications, as opposed to 26.1% prewarning. CONCLUSIONS: After the warning, there was a small decline in the use of atypical antipsychotics and no evidence of substitution of other psychotropic medications.
Authors: Brianne L Olivieri-Mui; John W Devlin; Aileen Ochoa; Danielle Schenck; Becky Briesacher Journal: Aging Ment Health Date: 2017-01-12 Impact factor: 3.658
Authors: Annelore H van Dalen-Kok; Marjoleine J C Pieper; Margot W M de Waal; Albert Lukas; Bettina S Husebo; Wilco P Achterberg Journal: BMC Geriatr Date: 2015-04-19 Impact factor: 3.921
Authors: Shamia Hoque; Brian J Chen; Martin W Schoen; Kenneth R Carson; Jesse Keller; Bartlett J Witherspoon; Kevin B Knopf; Y Tony Yang; Benjamin Schooley; Chadi Nabhan; Oliver Sartor; Paul R Yarnold; Paul Ray; Laura Bobolts; William J Hrushesky; Michael Dickson; Charles L Bennett Journal: PLoS One Date: 2020-06-25 Impact factor: 3.240
Authors: Annalisa Rubino; Myrlene Sanon; Michael L Ganz; Alex Simpson; Miriam C Fenton; Sumit Verma; Ann Hartry; Ross A Baker; Ruth A Duffy; Keva Gwin; Howard Fillit Journal: JAMA Netw Open Date: 2020-04-01