MOTIVATION: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking. RESULTS: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
MOTIVATION: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking. RESULTS: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
Authors: H M Berman; J Westbrook; Z Feng; G Gilliland; T N Bhat; H Weissig; I N Shindyalov; P E Bourne Journal: Nucleic Acids Res Date: 2000-01-01 Impact factor: 16.971
Authors: M Ashburner; C A Ball; J A Blake; D Botstein; H Butler; J M Cherry; A P Davis; K Dolinski; S S Dwight; J T Eppig; M A Harris; D P Hill; L Issel-Tarver; A Kasarskis; S Lewis; J C Matese; J E Richardson; M Ringwald; G M Rubin; G Sherlock Journal: Nat Genet Date: 2000-05 Impact factor: 38.330
Authors: Jason E Stajich; David Block; Kris Boulez; Steven E Brenner; Stephen A Chervitz; Chris Dagdigian; Georg Fuellen; James G R Gilbert; Ian Korf; Hilmar Lapp; Heikki Lehväslaiho; Chad Matsalla; Chris J Mungall; Brian I Osborne; Matthew R Pocock; Peter Schattner; Martin Senger; Lincoln D Stein; Elia Stupka; Mark D Wilkinson; Ewan Birney Journal: Genome Res Date: 2002-10 Impact factor: 9.043
Authors: Nicole C Allen; Sachin Bagade; Matthew B McQueen; John P A Ioannidis; Fotini K Kavvoura; Muin J Khoury; Rudolph E Tanzi; Lars Bertram Journal: Nat Genet Date: 2008-07 Impact factor: 38.330
Authors: S I Shyn; J Shi; J B Kraft; J B Potash; J A Knowles; M M Weissman; H A Garriock; J S Yokoyama; P J McGrath; E J Peters; W A Scheftner; W Coryell; W B Lawson; D Jancic; P V Gejman; A R Sanders; P Holmans; S L Slager; D F Levinson; S P Hamilton Journal: Mol Psychiatry Date: 2009-12-29 Impact factor: 15.992
Authors: Dheeraj R Bobbili; Dennis Lal; Patrick May; Eva M Reinthaler; Kamel Jabbari; Holger Thiele; Michael Nothnagel; Wiktor Jurkowski; Martha Feucht; Peter Nürnberg; Holger Lerche; Fritz Zimprich; Roland Krause; Bernd A Neubauer; Eva M Reinthaler; Fritz Zimprich; Martha Feucht; Hannelore Steinböck; Birgit Neophytou; Julia Geldner; Ursula Gruber-Sedlmayr; Edda Haberlandt; Gabriel M Ronen; Janine Altmüller; Dennis Lal; Peter Nürnberg; Thomas Sander; Holger Thiele; Roland Krause; Patrick May; Rudi Balling; Holger Lerche; Bernd A Neubauer Journal: Eur J Hum Genet Date: 2018-01-22 Impact factor: 4.246
Authors: Yun Li; Haoyi Wang; Julien Muffat; Albert W Cheng; David A Orlando; Jakob Lovén; Show-Ming Kwok; Danielle A Feldman; Helen S Bateup; Qing Gao; Dirk Hockemeyer; Maisam Mitalipova; Caroline A Lewis; Matthew G Vander Heiden; Mriganka Sur; Richard A Young; Rudolf Jaenisch Journal: Cell Stem Cell Date: 2013-10-03 Impact factor: 24.633
Authors: Ken H Loh; Philipp S Stawski; Austin S Draycott; Namrata D Udeshi; Emily K Lehrman; Daniel K Wilton; Tanya Svinkina; Thomas J Deerinck; Mark H Ellisman; Beth Stevens; Steven A Carr; Alice Y Ting Journal: Cell Date: 2016-08-25 Impact factor: 41.582