| Literature DB >> 22284812 |
Lucas Lopardi Franco1, Mauro Vieira de Almeida, Luiz Francisco Rocha E Silva, Pedro Paulo Ribeiro Vieira, Adrian Martin Pohlit, Marcelo Siqueira Valle.
Abstract
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC(50) ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.Entities:
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Year: 2012 PMID： 22284812 DOI： 10.1111/j.1747-0285.2012.01345.x
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817