STUDY OBJECTIVE: To compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function. DESIGN: Meta-analysis. SETTING: University-affiliated hospital. MEASUREMENTS: A systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied. MAIN RESULTS: There was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79). CONCLUSION: Anesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancer patients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.
STUDY OBJECTIVE: To compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function. DESIGN: Meta-analysis. SETTING: University-affiliated hospital. MEASUREMENTS: A systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied. MAIN RESULTS: There was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79). CONCLUSION: Anesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancerpatients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.
Authors: Andrew J Page; Aslam Ejaz; Gaya Spolverato; Tiffany Zavadsky; Michael C Grant; Daniel J Galante; Elizabeth C Wick; Matthew Weiss; Martin A Makary; Christopher L Wu; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2014-12-04 Impact factor: 3.452
Authors: H Lavon; P Matzner; A Benbenishty; L Sorski; E Rossene; R Haldar; E Elbaz; J P Cata; V Gottumukkala; S Ben-Eliyahu Journal: Br J Anaesth Date: 2017-11-23 Impact factor: 9.166
Authors: Jin Sun Cho; Mi-Hyang Lee; Seung Il Kim; Seho Park; Hyung Seok Park; Ein Oh; Jong Ho Lee; Bon-Nyeo Koo Journal: Int J Med Sci Date: 2017-08-18 Impact factor: 3.738