Literature DB >> 22283816

Natural products as leads for tuberculosis drug development.

Christine E Salomon1, Lori E Schmidt.   

Abstract

New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.

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Year:  2012        PMID： 22283816     DOI： 10.2174/156802612799984526

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  11 in total

Review 1.  The tuberculosis drug discovery and development pipeline and emerging drug targets.

Authors:  Khisimuzi Mdluli; Takushi Kaneko; Anna Upton
Journal:  Cold Spring Harb Perspect Med       Date:  2015-01-29       Impact factor: 6.915

2.  Exposure to Nepalese Propolis Alters the Metabolic State of Mycobacterium tuberculosis.

Authors:  Rafał Sawicki; Jarosław Widelski; Piotr Okińczyc; Wiesław Truszkiewicz; Joanna Glous; Elwira Sieniawska
Journal:  Front Microbiol       Date:  2022-06-23       Impact factor: 6.064

3.  Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy.

Authors:  Sudharsana Sundarrajan; Sajitha Lulu; Mohanapriya Arumugam
Journal:  J Mol Model       Date:  2015-09-01       Impact factor: 1.810

4.  Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis.

Authors:  Ricardo Escarcena; Jonathan Perez-Meseguer; Esther Del Olmo; Blanca Alanis-Garza; Elvira Garza-González; Ricardo Salazar-Aranda; Noemí Waksman de Torres
Journal:  Molecules       Date:  2015-04-21       Impact factor: 4.411

5.  Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach.

Authors:  Mohammad Tuhin Ali; Natalia Blicharska; Jamil A Shilpi; Veronique Seidel
Journal:  Sci Rep       Date:  2018-08-16       Impact factor: 4.379

6.  A significant therapeutic effect of silymarin administered alone, or in combination with chemotherapy, in experimental pulmonary tuberculosis caused by drug-sensitive or drug-resistant strains: In vitro and in vivo studies.

Authors:  Edén M Rodríguez-Flores; Dulce Mata-Espinosa; Jorge Barrios-Payan; Brenda Marquina-Castillo; Mauricio Castañón-Arreola; Rogelio Hernández-Pando
Journal:  PLoS One       Date:  2019-05-30       Impact factor: 3.240

7.  Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG).

Authors:  Rana M Qasaymeh; Dino Rotondo; Carel B Oosthuizen; Namrita Lall; Veronique Seidel
Journal:  Plants (Basel)       Date:  2019-11-06

8.  Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition.

Authors:  Haoxin Li; Andrew Cowie; John A Johnson; Duncan Webster; Christopher J Martyniuk; Christopher A Gray
Journal:  BMC Genomics       Date:  2016-08-11       Impact factor: 3.969

9.  Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis.

Authors:  María T García; David Carreño; José M Tirado-Vélez; María J Ferrándiz; Liliana Rodrigues; Begoña Gracia; Mónica Amblar; José A Ainsa; Adela G de la Campa
Journal:  Front Microbiol       Date:  2018-07-24       Impact factor: 5.640

Review 10.  Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds.

Authors:  Alfonsus Alvin; Kristin I Miller; Brett A Neilan
Journal:  Microbiol Res       Date:  2014-01-15       Impact factor: 5.415
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