OBJECTIVE: To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin. METHODS: SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release studies were conducted in rats. RESULTS: Maximum EE% of 90.0, 91.6 and 83.0% were obtained for SLMs formed with SRMS 1:1, 1:2 and 2:1, respectively. Stable, spherical and smooth SLMs of size range 9.80 ± 1.46 µm to 33.30 ± 6.42 µm were produced. The release of gentamicin in phosphate buffer varied widely with the lipid contents. Moreover, significant (p < 0.05) amount of gentamicin was released in vivo from the SLMs. CONCLUSION: SRMS-based SLMs would likely offer a reliable means of delivering gentamicin intramuscularly.
OBJECTIVE: To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin. METHODS: SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release studies were conducted in rats. RESULTS: Maximum EE% of 90.0, 91.6 and 83.0% were obtained for SLMs formed with SRMS 1:1, 1:2 and 2:1, respectively. Stable, spherical and smooth SLMs of size range 9.80 ± 1.46 µm to 33.30 ± 6.42 µm were produced. The release of gentamicin in phosphate buffer varied widely with the lipid contents. Moreover, significant (p < 0.05) amount of gentamicin was released in vivo from the SLMs. CONCLUSION: SRMS-based SLMs would likely offer a reliable means of delivering gentamicin intramuscularly.
Authors: Franklin C Kenechukwu; Mumuni A Momoh; Emmanuel C Umeyor; Emmanuel M Uronnachi; Anthony A Attama Journal: Int J Pharm Investig Date: 2016 Jan-Mar
Authors: Giada Botti; Anna Bianchi; Barbara Pavan; Paola Tedeschi; Valentina Albanese; Luca Ferraro; Federico Spizzo; Lucia Del Bianco; Alessandro Dalpiaz Journal: Int J Environ Res Public Health Date: 2022-08-25 Impact factor: 4.614