Philip V Peplow1, Tzu-Yun Chung, G David Baxter. 1. Department of Anatomy & Structural Biology, School of Physiotherapy, University of Otago, New Zealand. phil.peplow@stonebow.otago.ac.nz
Abstract
OBJECTIVE: The purpose of this study was to review studies of photodynamic therapy (PDT) on wound healing and cells in vitro, to assess the effects of such therapy. BACKGROUND DATA: PDT is used to treat tumors. When activated by light of a specific wavelength, the photosensitizer produces reactive oxygen species (ROS) that kill tumor cells. Low levels of ROS may induce cellular proliferation. METHODS: Research articles investigating PDT on wound healing and cells in vitro published up to August 2010 were retrieved from library sources, PubMed and Medline databases, reference lists of articles, and searches of relevant journals. RESULTS: The studies indicated that use of various photosensitizers combined with laser irradiation led to improved wound outcomes. For most in vitro studies, there was a decrease in cell growth or viability. CONCLUSIONS: PDT improved healing outcomes in several animal wound models, but mainly had an inhibitory effect on cells in vitro. These findings strongly support PDT for wound healing.
OBJECTIVE: The purpose of this study was to review studies of photodynamic therapy (PDT) on wound healing and cells in vitro, to assess the effects of such therapy. BACKGROUND DATA: PDT is used to treat tumors. When activated by light of a specific wavelength, the photosensitizer produces reactive oxygen species (ROS) that kill tumor cells. Low levels of ROS may induce cellular proliferation. METHODS: Research articles investigating PDT on wound healing and cells in vitro published up to August 2010 were retrieved from library sources, PubMed and Medline databases, reference lists of articles, and searches of relevant journals. RESULTS: The studies indicated that use of various photosensitizers combined with laser irradiation led to improved wound outcomes. For most in vitro studies, there was a decrease in cell growth or viability. CONCLUSIONS: PDT improved healing outcomes in several animal wound models, but mainly had an inhibitory effect on cells in vitro. These findings strongly support PDT for wound healing.
Authors: Helen Reinhart Camargo Catarino; Natália Pereira de Godoy; Nayara Kastem Scharlack; Lia Mara Grosso Neves; Fernanda Oliveira de Gaspari de Gaspi; Marcelo Augusto Marreto Esquisatto; Maria Esméria Corezola do Amaral; Fernanda Aparecida Sampaio Mendonça; Gláucia Maria Tech dos Santos Journal: Lasers Med Sci Date: 2015-01-20 Impact factor: 3.161
Authors: Valéria Ferreira-Silva; Fernando L Primo; Munira M A Baqui; Danielle A R Magalhães; Maristela D Orellana; Andrielle Castilho-Fernandes; Mario C Cruz; Niehls O S Câmara; Dimas T Covas; Antonio C Tedesco Journal: Stem Cell Rev Rep Date: 2018-08 Impact factor: 5.739
Authors: Hasan Gündoğar; Süleyman Ziya Şenyurt; Kamile Erciyas; Mehmet Yalım; Kemal Üstün Journal: Lasers Med Sci Date: 2016-08-14 Impact factor: 3.161
Authors: Asheesh Gupta; Pinar Avci; Magesh Sadasivam; Rakkiyappan Chandran; Nivaldo Parizotto; Daniela Vecchio; Wanessa C M A de Melo; Tianhong Dai; Long Y Chiang; Michael R Hamblin Journal: Biotechnol Adv Date: 2012-08-21 Impact factor: 14.227
Authors: João Alves dos Reis; Fabíola Bastos de Carvalho; Renan Ferreira Trindade; Patrícia Nascimento de Assis; Paulo Fernando de Almeida; Antônio Luiz Barbosa Pinheiro Journal: Lasers Med Sci Date: 2013-08-25 Impact factor: 3.161