| Literature DB >> 22283567 |
Ahmad A Ibrahim1, Divya Nalla, Maxwell Van Raaphorst, Nessan J Kerrigan.
Abstract
In this Communication we describe an unprecedented catalytic asymmetric heterodimerization of ketenes of wide substrate scope. The alkaloid-catalyzed method provides access to ketene heterodimer β-lactones and allows even two different monosubstituted ketenes to be cross-dimerized, with excellent enantioselectivity (17 examples with ≥90% ee) and excellent heterodimer regioselectivity observed in all cases.Entities:
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Year: 2012 PMID： 22283567 DOI： 10.1021/ja211678m
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419