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Literature DB >> 2228250

Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

Abstract

Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incubated with Fab fragments but a confluent binding on cells incubated with intact MAb 4C12.

Entities: Chemical Species

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Year: 1990 PMID： 2228250 PMCID： PMC313733 DOI： 10.1128/iai.58.11.3810-3812.1990

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. Identification of wall-specific antigens synthesized during germ tube formation by Candida albicans.

Authors: M Casanova; M L Gil; L Cardeñoso; J P Martinez; R Sentandreu
Journal: Infect Immun Date: 1989-01 Impact factor: 3.441

2. Inhibition of cell-cell binding at the aggregation stage of Dictyostelium discoideum development by monoclonal antibodies directed against an 80,000-dalton surface glycoprotein.

Authors: C H Siu; T Y Lam; A H Choi
Journal: J Biol Chem Date: 1985-12-15 Impact factor: 5.157

3. Formation of a new cell wall by protoplasts of Candida albicans: effect of papulacandin B, tunicamycin and Nikkomycin.

Authors: M V Elorza; A Murgui; H Rico; F Miragall; R Sentandreu
Journal: J Gen Microbiol Date: 1987-08

4. Effect of papulacandin B and calcofluor white on the incorporation of mannoproteins in the wall of Candida albicans blastospores.

Authors: A Murgui; M V Elorza; R Sentandreu
Journal: Biochim Biophys Acta Date: 1985-08-16

5. Tunicamycin and papulacandin B inhibit incorporation of specific mannoproteins into the wall of Candida albicans regenerating protoplasts.

Authors: A Murgui; M V Elorza; R Sentandreu
Journal: Biochim Biophys Acta Date: 1986-12-10

6. Analysis of cell wall extracts of Candida albicans by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot techniques.

Authors: J Ponton; J M Jones
Journal: Infect Immun Date: 1986-09 Impact factor: 3.441

Review 7. Antigenic variability of Candida albicans.

Authors: D Poulain; V Hopwood; A Vernes
Journal: Crit Rev Microbiol Date: 1985 Impact factor: 7.624

8. Effect of tunicamycin on germ tube and yeast bud formation in Candida albicans.

Authors: W L Chaffin
Journal: J Gen Microbiol Date: 1985-08

9. Antigenic differences in the surface mannoproteins of Candida albicans as revealed by monoclonal antibodies.

Authors: P M Sundstrom; M R Tam; E J Nichols; G E Kenny
Journal: Infect Immun Date: 1988-03 Impact factor: 3.441

10. Calcofluor white alters the assembly of chitin fibrils in Saccharomyces cerevisiae and Candida albicans cells.

Authors: M V Elorza; H Rico; R Sentandreu
Journal: J Gen Microbiol Date: 1983-05

24 in total

1. Characterization of cell wall proteins from yeast and mycelial cells of Candida albicans by labelling with biotin: comparison with other techniques.

Authors: M Casanova; J L Lopez-Ribot; J P Martinez; R Sentandreu
Journal: Infect Immun Date: 1992-11 Impact factor: 3.441

10. A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities.

Authors: María D Moragues; Miren J Omaetxebarria; Natalia Elguezabal; María J Sevilla; Stefania Conti; Luciano Polonelli; José Pontón
Journal: Infect Immun Date: 2003-09 Impact factor: 3.441

Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

1. Identification of wall-specific antigens synthesized during germ tube formation by Candida albicans.

2. Inhibition of cell-cell binding at the aggregation stage of Dictyostelium discoideum development by monoclonal antibodies directed against an 80,000-dalton surface glycoprotein.

3. Formation of a new cell wall by protoplasts of Candida albicans: effect of papulacandin B, tunicamycin and Nikkomycin.

4. Effect of papulacandin B and calcofluor white on the incorporation of mannoproteins in the wall of Candida albicans blastospores.

5. Tunicamycin and papulacandin B inhibit incorporation of specific mannoproteins into the wall of Candida albicans regenerating protoplasts.

6. Analysis of cell wall extracts of Candida albicans by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot techniques.

Review 7. Antigenic variability of Candida albicans.

8. Effect of tunicamycin on germ tube and yeast bud formation in Candida albicans.

9. Antigenic differences in the surface mannoproteins of Candida albicans as revealed by monoclonal antibodies.

10. Calcofluor white alters the assembly of chitin fibrils in Saccharomyces cerevisiae and Candida albicans cells.

1. Characterization of cell wall proteins from yeast and mycelial cells of Candida albicans by labelling with biotin: comparison with other techniques.

Review 2. New concepts in antibody-mediated immunity.

3. Biochemical characterization of Candida albicans epitopes that can elicit protective and nonprotective antibodies.

4. Hemin induces germ tube formation in Candida albicans.

Review 5. Anticandidal immunity and vaginitis: novel opportunities for immune intervention.

Review 6. Antibody immunity and invasive fungal infections.

Review 7. Cell wall and secreted proteins of Candida albicans: identification, function, and expression.

8. New monoclonal antibody specific for Candida albicans germ tube.

9. Common and form-specific cell wall antigens of Candida albicans as released by chemical and enzymatic treatments.

10. A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities.