BACKGROUND: Scleroderma is a fairly rare connective tissue disease whose autoantibody profile is associated with different clinical manifestations. The prevalence of autoantibodies in scleroderma is influenced by race and genetics. OBJECTIVE: To study the prevalence of anti-Scl-70, anti-centromere (ACA) and anti-U1-RNP antibodies in patients with scleroderma in southern Brazil and verify their association with clinical manifestations of the disease. METHODS: A retrospective study involving 66 patients with scleroderma for the presence of anti-Scl-70, anti-centromere and anti-U1-RNP and of clinical manifestations such as Raynaud's phenomenon, digital micro scars, digital necrosis, telangiectasias, calcinosis, pulmonary fibrosis, pleuritis, pericarditis, cardiomyopathy, arthralgia and arthritis, skin sclerosis, joint contractures, tendon friction rubs, pulmonary hypertension, esophageal disorders and renal crisis. RESULTS: The prevalence of anti-Scl-70 was 17.8% , that of ACA was 33.3% and the prevalence of U1 RNP was 11.8%. Anti-Scl-70 was associated with the diffuse form of the disease (p = 0.015), presence of cardiomyopathies (p = 0.016) and digital micro scars (p = 0.05). Anti-centromere was more common in the limited form, although it was not statistically significant, and had a protective role associated with cardiomyopathies (p = 0.005). Anti-U1-RNP was more common in the overlap forms (p = 0.0004). CONCLUSION: The prevalence and profile of clinical associations of autoantibodies in Brazilian patients with scleroderma are similar to those found in the literature.
BACKGROUND:Scleroderma is a fairly rare connective tissue disease whose autoantibody profile is associated with different clinical manifestations. The prevalence of autoantibodies in scleroderma is influenced by race and genetics. OBJECTIVE: To study the prevalence of anti-Scl-70, anti-centromere (ACA) and anti-U1-RNP antibodies in patients with scleroderma in southern Brazil and verify their association with clinical manifestations of the disease. METHODS: A retrospective study involving 66 patients with scleroderma for the presence of anti-Scl-70, anti-centromere and anti-U1-RNP and of clinical manifestations such as Raynaud's phenomenon, digital micro scars, digital necrosis, telangiectasias, calcinosis, pulmonary fibrosis, pleuritis, pericarditis, cardiomyopathy, arthralgia and arthritis, skin sclerosis, joint contractures, tendon friction rubs, pulmonary hypertension, esophageal disorders and renal crisis. RESULTS: The prevalence of anti-Scl-70 was 17.8% , that of ACA was 33.3% and the prevalence of U1 RNP was 11.8%. Anti-Scl-70 was associated with the diffuse form of the disease (p = 0.015), presence of cardiomyopathies (p = 0.016) and digital micro scars (p = 0.05). Anti-centromere was more common in the limited form, although it was not statistically significant, and had a protective role associated with cardiomyopathies (p = 0.005). Anti-U1-RNP was more common in the overlap forms (p = 0.0004). CONCLUSION: The prevalence and profile of clinical associations of autoantibodies in Brazilian patients with scleroderma are similar to those found in the literature.
Authors: J N Kimmel; D A Carlson; M Hinchcliff; M A Carns; K A Aren; J Lee; J E Pandolfino Journal: Neurogastroenterol Motil Date: 2016-02-27 Impact factor: 3.598
Authors: María Pilar Cruz-Domínguez; Grettel García-Collinot; Miguel A Saavedra; Gabriela Medina; Rosa Angélica Carranza-Muleiro; Olga Lidia Vera-Lastra; Luis J Jara Journal: Clin Rheumatol Date: 2016-10-07 Impact factor: 2.980
Authors: Pia Moinzadeh; Elisabeth Aberer; Keihan Ahmadi-Simab; Norbert Blank; Joerg H W Distler; Gerhard Fierlbeck; Ekkehard Genth; Claudia Guenther; Ruediger Hein; Joerg Henes; Lena Herich; Ilka Herrgott; Ina Koetter; Alexander Kreuter; Thomas Krieg; Kathrin Kuhr; Hanns-Martin Lorenz; Florian Meier; Inga Melchers; Hartwig Mensing; Ulf Mueller-Ladner; Christiane Pfeiffer; Gabriela Riemekasten; Miklós Sárdy; Marc Schmalzing; Cord Sunderkoetter; Laura Susok; Ingo H Tarner; Peter Vaith; Margitta Worm; Gottfried Wozel; Gabriele Zeidler; Nicolas Hunzelmann Journal: Ann Rheum Dis Date: 2014-01-03 Impact factor: 19.103
Authors: Fiaz Alam; Hani Malallah Abdulaziz; Irfan Ul Haq; Salah Mohamed Mahdy; Abdul Rahim Mohammed Siam; Prem Chandra; Samar Al Emadi Journal: Qatar Med J Date: 2019-12-24