OBJECTIVE: Advanced glycation end products (AGEs) activate the intracellular Nuclear Factor-κB pathway in endothelial cells, leading to production of endothelin-1 (ET-1), a peptide which causes endothelial dysfunction. The aim of the present study was to assess ΕΤ-1 and AGEs levels in women with polycystic ovary syndrome (PCOS) and controls and to investigate any potential relationship between them. DESIGN: Metabolic and hormonal data from 75 women with PCOS and 25 controls, matched for age and ΒΜΙ were analyzed and correlated to AGEs and ET-1 levels. RESULTS: Serum levels of ΕΤ-1 (1.55±0.13 vs. 0.37±0.10 pmol/l, p:0.003) and AGEs (8.34±1,81 vs. 5.77±0.78U/ml, p:0.002) were significantly higher in the PCOS group. ΕΤ-1 was correlated with AGES (r:0.54, p<0.001), Testosterone (r: 0.38, p<0.001), ΔΑ4 (r: 0.41, p<0.001) and FAI (r: 0.21, p<0.05). However, multiple linear regression analysis in the total study population showed that ΕΤ-1 was positively associated only with AGES (β: 0.22, p<0.001). CONCLUSIONS: ET-1 levels were positively and strongly associated with AGEs in both PCOS women and controls, suggesting that the detrimental effect of AGEs on endothelial cells may involve increased ET-1 production.
OBJECTIVE: Advanced glycation end products (AGEs) activate the intracellular Nuclear Factor-κB pathway in endothelial cells, leading to production of endothelin-1 (ET-1), a peptide which causes endothelial dysfunction. The aim of the present study was to assess ΕΤ-1 and AGEs levels in women with polycystic ovary syndrome (PCOS) and controls and to investigate any potential relationship between them. DESIGN: Metabolic and hormonal data from 75 women with PCOS and 25 controls, matched for age and ΒΜΙ were analyzed and correlated to AGEs and ET-1 levels. RESULTS: Serum levels of ΕΤ-1 (1.55±0.13 vs. 0.37±0.10 pmol/l, p:0.003) and AGEs (8.34±1,81 vs. 5.77±0.78U/ml, p:0.002) were significantly higher in the PCOS group. ΕΤ-1 was correlated with AGES (r:0.54, p<0.001), Testosterone (r: 0.38, p<0.001), ΔΑ4 (r: 0.41, p<0.001) and FAI (r: 0.21, p<0.05). However, multiple linear regression analysis in the total study population showed that ΕΤ-1 was positively associated only with AGES (β: 0.22, p<0.001). CONCLUSIONS:ET-1 levels were positively and strongly associated with AGEs in both PCOS women and controls, suggesting that the detrimental effect of AGEs on endothelial cells may involve increased ET-1 production.
Authors: H Yilmaz; H T Celik; O Ozdemir; D Kalkan; M Namuslu; S Abusoglu; C R Atalay; R Yigitoglu Journal: J Endocrinol Invest Date: 2014-01-09 Impact factor: 4.256
Authors: Suttira Intapad; Norma B Ojeda; Elliott Varney; Thomas P Royals; Barbara T Alexander Journal: Hypertension Date: 2015-10-12 Impact factor: 10.190
Authors: Michelle Achterberg; Jiska S Peper; Anna C K van Duijvenvoorde; René C W Mandl; Eveline A Crone Journal: J Neurosci Date: 2016-02-10 Impact factor: 6.167