OBJECTIVE: The aim of our study was to determine the usefulness of the aortic knob width (AKW) in the assessment of subclinical atherosclerosis in hypertensive patients. METHODS: In this study on diagnostic accuracy, 374 consecutive hypertensive patients with at least one cardiovascular risk factor were enrolled. AKW was measured on chest X-ray. Cardio-ankle vascular index (CAVI) was measured by VaSera-1000 CAVI instrument. The diagnostic value of AKW was assessed using ROC analysis. RESULTS: There was a significant correlation between aortic knob width and CAVI (r=0.45, p<0.001), age (0.39, p<0.001), systolic (r=0.17, p<0.001), diastolic (r=0.23, p<0.001) and mean (r=0.2, p<0.001) blood pressures. In linear regression analysis CAVI (β=0.3, 95% CI 0.33-0.98, p<0.001), age (β=0.3, 95% CI 0.09 - 0.21, p<0.001) and diastolic blood pressure β=0.2, 95% CI 0.08-1.9, p<0.001) were independently associated with AKW. It was significantly higher in patients with subclinical atherosclerosis (CAVI ≥9) than borderline (8 ≤CAVI <9) (41.4±5.5 versus 36.7±5.3 mm, p<0.001) and healthy (CAVI <8) subjects (41.4±5.5 versus 35.5±4.3 mm, p<0.001). Analysis using the ROC curve has demonstrated that aortic knob of 41 mm constitutes the cut-off value for the presence of subclinical atherosclerosis with 71% sensitivity and 77% specificity (AUC-0.67, 95% CI 0.51-0.82). CONCLUSION: Observation of aortic knob on chest X-ray in hypertensive patients may provide important predictive information of subclinical atherosclerosis.
OBJECTIVE: The aim of our study was to determine the usefulness of the aortic knob width (AKW) in the assessment of subclinical atherosclerosis in hypertensivepatients. METHODS: In this study on diagnostic accuracy, 374 consecutive hypertensivepatients with at least one cardiovascular risk factor were enrolled. AKW was measured on chest X-ray. Cardio-ankle vascular index (CAVI) was measured by VaSera-1000 CAVI instrument. The diagnostic value of AKW was assessed using ROC analysis. RESULTS: There was a significant correlation between aortic knob width and CAVI (r=0.45, p<0.001), age (0.39, p<0.001), systolic (r=0.17, p<0.001), diastolic (r=0.23, p<0.001) and mean (r=0.2, p<0.001) blood pressures. In linear regression analysis CAVI (β=0.3, 95% CI 0.33-0.98, p<0.001), age (β=0.3, 95% CI 0.09 - 0.21, p<0.001) and diastolic blood pressure β=0.2, 95% CI 0.08-1.9, p<0.001) were independently associated with AKW. It was significantly higher in patients with subclinical atherosclerosis (CAVI ≥9) than borderline (8 ≤CAVI <9) (41.4±5.5 versus 36.7±5.3 mm, p<0.001) and healthy (CAVI <8) subjects (41.4±5.5 versus 35.5±4.3 mm, p<0.001). Analysis using the ROC curve has demonstrated that aortic knob of 41 mm constitutes the cut-off value for the presence of subclinical atherosclerosis with 71% sensitivity and 77% specificity (AUC-0.67, 95% CI 0.51-0.82). CONCLUSION: Observation of aortic knob on chest X-ray in hypertensivepatients may provide important predictive information of subclinical atherosclerosis.
Authors: Ali Rıza Akyüz; Turhan Turan; Musluhittin Emre Erkuş; İsmail Gürbak; Selim Kul; Levent Korkmaz; Mustafa Tarık Ağaç; Şükrü Çelik Journal: Wien Klin Wochenschr Date: 2016-03-14 Impact factor: 1.704
Authors: Leticia Gomez-Sanchez; Luis García-Ortiz; José I Recio-Rodríguez; Maria C Patino-Alonso; Cristina Agudo-Conde; Fernando Rigo; Rafel Ramos; Ruth Martí; Manuel A Gomez-Marcos Journal: PLoS One Date: 2015-04-17 Impact factor: 3.240
Authors: Jose A Maderuelo-Fernandez; Jose I Recio-Rodriguez; Irene A Garcia-Yu; Luis Garcia-Ortiz; Manuel A Gómez-Marcos; Rosario Alonso-Dominguez; Jesus Gonzalez-Sanchez; Sara Mora-Simon; Susana González-Manzano; Emiliano Rodriguez-Sanchez Journal: BMJ Open Date: 2018-12-14 Impact factor: 2.692
Authors: Manuel A Gomez-Marcos; Carlos Martinez-Salgado; Rogelio Gonzalez-Sarmiento; Jesus Ma Hernandez-Rivas; Pedro L Sanchez-Fernandez; Jose I Recio-Rodriguez; Emiliano Rodriguez-Sanchez; Luis García-Ortiz Journal: BMJ Open Date: 2016-06-07 Impact factor: 2.692