Literature DB >> 22281766

The persistence of a silent memory.

Mikel Zaratiegui, Robert Martienssen.   

Abstract

One of the most striking properties of RNA interference (RNAi) in Caenorhabditis elegans is its persistence in offspring after the triggering double-stranded RNA (dsRNA) has disappeared. A new study reveals that a heterochromatic silencing mark is deposited around the targets of RNAi and is transmitted through generations. These results show that RNAi can induce stable and heritable chromatin modifications in animals.

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Year:  2012        PMID： 22281766      PMCID： PMC5556923          DOI： 10.1038/ng.1088

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

Authors:  Elizabeth H Bayne; Sharon A White; Alexander Kagansky; Dominika A Bijos; Luis Sanchez-Pulido; Kwang-Lae Hoe; Dong-Uk Kim; Han-Oh Park; Chris P Ponting; Juri Rappsilber; Robin C Allshire
Journal:  Cell       Date:  2010-03-05       Impact factor: 41.582

2.  Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.

Authors:  Shouhong Guang; Aaron F Bochner; Kirk B Burkhart; Nick Burton; Derek M Pavelec; Scott Kennedy
Journal:  Nature       Date:  2010-06-13       Impact factor: 49.962

3.  Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.

Authors:  Manika Pal-Bhadra; Boris A Leibovitch; Sumit G Gandhi; Madhusudana Rao Chikka; Madhusudana Rao; Utpal Bhadra; James A Birchler; Sarah C R Elgin
Journal:  Science       Date:  2004-01-30       Impact factor: 47.728

4.  Epigenetic reprogramming and small RNA silencing of transposable elements in pollen.

Authors:  R Keith Slotkin; Matthew Vaughn; Filipe Borges; Milos Tanurdzić; Jörg D Becker; José A Feijó; Robert A Martienssen
Journal:  Cell       Date:  2009-02-06       Impact factor: 41.582

5.  A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

Authors:  Alexei A Aravin; Ravi Sachidanandam; Deborah Bourc'his; Christopher Schaefer; Dubravka Pezic; Katalin Fejes Toth; Timothy Bestor; Gregory J Hannon
Journal:  Mol Cell       Date:  2008-09-26       Impact factor: 17.970

6.  Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.

Authors:  Thomas A Volpe; Catherine Kidner; Ira M Hall; Grace Teng; Shiv I S Grewal; Robert A Martienssen
Journal:  Science       Date:  2002-08-22       Impact factor: 47.728

7.  Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans.

Authors:  Oded Rechavi; Gregory Minevich; Oliver Hobert
Journal:  Cell       Date:  2011-11-23       Impact factor: 41.582

8.  Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Authors:  Francisca E Reyes-Turcu; Ke Zhang; Martin Zofall; Eesin Chen; Shiv I S Grewal
Journal:  Nat Struct Mol Biol       Date:  2011-09-04       Impact factor: 15.369

9.  RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.

Authors:  Mikel Zaratiegui; Stephane E Castel; Danielle V Irvine; Anna Kloc; Jie Ren; Fei Li; Elisa de Castro; Laura Marín; An-Yun Chang; Derek Goto; W Zacheus Cande; Francisco Antequera; Benoit Arcangioli; Robert A Martienssen
Journal:  Nature       Date:  2011-10-16       Impact factor: 49.962

10.  Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.

Authors:  Mario Halic; Danesh Moazed
Journal:  Cell       Date:  2010-02-19       Impact factor: 41.582
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