Literature DB >> 22281230

GOSPEL: prospective survey of gout in France. Part I: design and patient characteristics (n = 1003).

Frédéric Lioté1, Sylvie Lancrenon, Sabine Lanz, Pascal Guggenbuhl, Charles Lambert, Alain Saraux, Pierre Chiarelli, Catherine Delva, Jean-Pierre Aubert, Hang-Korng Ea.   

Abstract

OBJECTIVES: To assess diagnoses and management of acute and chronic gout in primary care and rheumatology settings relative to 2006 European League Against Rheumatism (EULAR) gout recommendations. Secondary objectives were to describe patient demographics, clinical features, lifestyle modifications, and short- and mid-term outcomes.
METHODS: Prospective, cross-sectional, descriptive survey of patients with chronic gout, acute gout, or suspected gout, included by randomly selected general practitioners (GPs, n = 398) and rheumatologists (n = 109) between October 2008 and September 2009, in France. At the first visit, a structured questionnaire was completed. Each patient completed self-questionnaires at the first visit and 3 to 6 months later.
RESULTS: We included 1003 patients, including 879 (87.6%) males (mean age, 61.6 ± 11.4 years; 28.1% obese) and 124 (12.4%) females (70.2 ± 11.9 years; 33.1% obese). Mean disease duration was 8.0 ± 8.3 years and mean time since hyperuricemia diagnosis 8.2 ± 8.4 years. Mean annual number of flares was 1.9 ± 1.5. ACR criteria for gout were met in 855 pts. Gout was acute in 487 (48.6%) patients and chronic in 241 (24.4%). Tophi (19.4% of patients) were associated with disease duration but not gender or chronic kidney disease (CKD). The main co-morbidities were hypertension (53.8%), dyslipidemia (47.2%), and hyperglycemia/diabetes mellitus (15.0%). CKD 3-5 was present in 43% of patients but was identified by physicians in only 5.2%. CKD severity was significantly associated with age, gender, hypertension, and diuretic use.
CONCLUSION: This cohort will prove valuable for addressing the concordance with EULAR recommendations and for future studies of gout in everyday practice, most notably regarding metabolic syndrome, other co-morbidities, and identification of difficult-to-treat patients.
Copyright © 2012 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

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Year:  2012        PMID: 22281230     DOI: 10.1016/j.jbspin.2011.12.006

Source DB:  PubMed          Journal:  Joint Bone Spine        ISSN: 1297-319X            Impact factor:   4.929


  8 in total

Review 1.  Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

Authors:  Matthew J Roughley; John Belcher; Christian D Mallen; Edward Roddy
Journal:  Arthritis Res Ther       Date:  2015-04-01       Impact factor: 5.156

2.  Multiple Tophaceous Gout of Hand with Extensor Tendon Rupture.

Authors:  Haruki Tobimatsu; Masanori Nakayama; Yu Sakuma; Hitoshi Imamura; Koichiro Yano; Hiroko Itagaki; Katsunori Ikari
Journal:  Case Rep Orthop       Date:  2017-12-20

3.  Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study.

Authors:  Tristan Pascart; André Ramon; Sébastien Ottaviani; Julie Legrand; Vincent Ducoulombier; Eric Houvenagel; Laurène Norberciak; Pascal Richette; Fabio Becce; Paul Ornetti; Jean-François Budzik
Journal:  J Clin Med       Date:  2020-05-01       Impact factor: 4.241

4.  Ultrasonography and dual-energy computed tomography: impact for the detection of gouty deposits.

Authors:  Christoph Schwabl; Mihra Taljanovic; Gerlig Widmann; James Teh; Andrea S Klauser
Journal:  Ultrasonography       Date:  2020-10-02

5.  Simple Application and Adherence to Gout Guidelines Enables Disease Control: An Observational Study in French Referral Centres.

Authors:  Charlotte Jauffret; Sébastien Ottaviani; Augustin Latourte; Hang-Korng Ea; Sahara Graf; Frédéric Lioté; Thomas Bardin; Pascal Richette; Tristan Pascart
Journal:  J Clin Med       Date:  2022-09-28       Impact factor: 4.964

6.  Reduced glomerular function and prevalence of gout: NHANES 2009-10.

Authors:  Eswar Krishnan
Journal:  PLoS One       Date:  2012-11-27       Impact factor: 3.240

7.  Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study : MSU burden and risk of gout flare.

Authors:  Tristan Pascart; Agathe Grandjean; Benoist Capon; Julie Legrand; Nasser Namane; Vincent Ducoulombier; Marguerite Motte; Marie Vandecandelaere; Hélène Luraschi; Catherine Godart; Eric Houvenagel; Laurène Norberciak; Jean-François Budzik
Journal:  Arthritis Res Ther       Date:  2018-09-17       Impact factor: 5.156

8.  Non-steroidal anti-inflammatory drugs in chronic kidney disease: a systematic review of prescription practices and use in primary care.

Authors:  Claire Lefebvre; Jade Hindié; Michael Zappitelli; Robert W Platt; Kristian B Filion
Journal:  Clin Kidney J       Date:  2019-05-20
  8 in total

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