Literature DB >> 22280373

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme.

Xuhua Mo1, Junying Ma, Hongbo Huang, Bo Wang, Yongxiang Song, Si Zhang, Changsheng Zhang, Jianhua Ju.   

Abstract

The tirandamycins (TAMs) are a small group of Streptomyces-derived natural products that target bacterial RNA polymerase. Within the TAM biosynthetic cluster, trdE encodes a glycoside hydrolase whose role in TAM biosynthesis has been undefined until now. We report that in vivo trdE inactivation leads to accumulation of pre-tirandamycin, the earliest intermediate released from its mixed polyketide/nonribosomal peptide biosynthetic assembly line. In vitro and site-directed mutagenesis studies showed that TrdE, a putative glycoside hydrolase, catalyzes in a highly atypical fashion the installation of the Δ(11,12) double bond during TAM biosynthesis.

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Year:  2012        PMID： 22280373     DOI： 10.1021/ja206713a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  8 in total

1.  Cytochrome P450 oxidase SlgO1 catalyzes the biotransformation of tirandamycin C to a new tirandamycin derivative.

Authors:  Xuhua Mo; Chun Gui; Song Yang
Journal:  3 Biotech       Date:  2019-02-09       Impact factor: 2.406

2.  Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.

Authors:  Xingwang Zhang; Zhong Li; Lei Du; George E Chlipala; Patricia C Lopez; Wei Zhang; David H Sherman; Shengying Li
Journal:  Tetrahedron Lett       Date:  2016-11-19       Impact factor: 2.415

3.  Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.

Authors:  Cristina Gómez; Dina H Horna; Carlos Olano; Carmen Méndez; José A Salas
Journal:  Microb Biotechnol       Date:  2012-06-22       Impact factor: 5.813

4.  Formation of the Δ(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase-like Enzyme.

Authors:  Chunyan Jiang; Zhen Qi; Qianjin Kang; Jing Liu; Ming Jiang; Linquan Bai
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-11       Impact factor: 15.336

5.  Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.

Authors:  Xuhua Mo; Chunrong Shi; Chun Gui; Yanjiao Zhang; Jianhua Ju; Qingji Wang
Journal:  Microb Cell Fact       Date:  2017-06-09       Impact factor: 5.328

6.  CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces.

Authors:  Chun Gui; Jiang Chen; Qing Xie; Xuhua Mo; Shanwen Zhang; Hua Zhang; Junying Ma; Qinglian Li; Yu-Cheng Gu; Jianhua Ju
Journal:  Commun Biol       Date:  2019-12-06

Review 7.  The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.

Authors:  Minghua Jiang; Senhua Chen; Jing Li; Lan Liu
Journal:  Mar Drugs       Date:  2020-02-15       Impact factor: 5.118

8.  Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.

Authors:  Mostafa E Rateb; Zhiguo Yu; Yijun Yan; Dong Yang; Tingting Huang; Sanja Vodanovic-Jankovic; Michael A Kron; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2013-05-29       Impact factor: 2.649
  8 in total

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