Literature DB >> 22277966

A virtual national laboratory for reengineering clinical translational science.

David M Dilts1, Daniel Rosenblum, William M Trochim.   

Abstract

Clinical research is burdened by inefficiencies and complexities, with a poor record of trial completion, none of which is desirable. The Clinical and Translational Science Award (CTSA) Consortium, including more than 60 clinical research institutions, supports a unified national effort to become, in effect, a virtual national laboratory designed to identify, implement, evaluate, and extend process improvements across all parts of clinical research, from conception to completion. If adequately supported by academic health centers, industry, and funding agencies, the Consortium could become a test bed for improvements that can dramatically reduce wasteful complexity, thus increasing the likelihood of clinical trial completion.

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Year:  2012        PMID: 22277966      PMCID: PMC3691381          DOI: 10.1126/scitranslmed.3002951

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN: 1946-6234            Impact factor:   17.956


  18 in total

1.  New drug development in the United States from 1963 to 1999.

Authors:  J A Dimasi
Journal:  Clin Pharmacol Ther       Date:  2001-05       Impact factor: 6.875

2.  Medicine. The NIH Roadmap.

Authors:  Elias Zerhouni
Journal:  Science       Date:  2003-10-03       Impact factor: 47.728

3.  What is translational research?

Authors:  Karen Birmingham
Journal:  Nat Med       Date:  2002-07       Impact factor: 53.440

4.  A national cancer clinical trials system for the 21st century: reinvigorating the NCI Cooperative Group Program.

Authors:  John F Scoggins; Scott D Ramsey
Journal:  J Natl Cancer Inst       Date:  2010-08-03       Impact factor: 13.506

5.  Early warning: an ailing canary in the mine.

Authors:  David M Dilts
Journal:  J Clin Oncol       Date:  2010-07-19       Impact factor: 44.544

Review 6.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.

Authors:  Steven M Paul; Daniel S Mytelka; Christopher T Dunwiddie; Charles C Persinger; Bernard H Munos; Stacy R Lindborg; Aaron L Schacht
Journal:  Nat Rev Drug Discov       Date:  2010-02-19       Impact factor: 84.694

7.  US cancer trials may go the way of the Oldsmobile.

Authors:  David Dilts
Journal:  Nat Med       Date:  2010-06       Impact factor: 53.440

8.  Medicine. Life cycle of translational research for medical interventions.

Authors:  Despina G Contopoulos-Ioannidis; George A Alexiou; Theodore C Gouvias; John P A Ioannidis
Journal:  Science       Date:  2008-09-05       Impact factor: 47.728

9.  Reengineering translational science: the time is right.

Authors:  Francis S Collins
Journal:  Sci Transl Med       Date:  2011-07-06       Impact factor: 17.956

10.  Invisible barriers to clinical trials: the impact of structural, infrastructural, and procedural barriers to opening oncology clinical trials.

Authors:  David M Dilts; Alan B Sandler
Journal:  J Clin Oncol       Date:  2006-10-01       Impact factor: 44.544

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  13 in total

1.  The CTSA Consortium's Catalog of Assets for Translational and Clinical Health Research (CATCHR).

Authors:  Jana Shirey-Rice; Brandy Mapes; Melissa Basford; Anneliese Zufelt; Firas Wehbe; Paul Harris; Michael Alcorn; David Allen; Margaret Arnim; Susan Autry; Michael S Briggs; Andrea Carnegie; Deborah Chavis-Keeling; Carlos De La Pena; Doris Dworschak; Julie Earnest; Terri Grieb; Marilyn Guess; Nathaniel Hafer; Tesheia Johnson; Amanda Kasper; Janice Kopp; Timothy Lockie; Vincetta Lombardo; Leslie McHale; Andrea Minogue; Beth Nunnally; Deanna O'Quinn; Kelly Peck; Kieran Pemberton; Cheryl Perry; Ginny Petrie; Andria Pontello; Rachel Posner; Bushra Rehman; Deborah Roth; Paulette Sacksteder; Samantha Scahill; Lorri Schieri; Rosemary Simpson; Anne Skinner; Kim Toussant; Alicia Turner; Elaine Van der Put; June Wasser; Chris D Webb; Maija Williams; Lori Wiseman; Laurel Yasko; Jill Pulley
Journal:  Clin Transl Sci       Date:  2014-01-23       Impact factor: 4.689

2.  Evaluating protocol lifecycle time intervals in HIV/AIDS clinical trials.

Authors:  Scott R Rosas; Jeffrey T Schouten; Dennis Dixon; Suresh Varghese; Marie T Cope; Joe Marci; Jonathan M Kagan
Journal:  Clin Trials       Date:  2014-06-30       Impact factor: 2.486

Review 3.  Integrated Genomic Medicine: A Paradigm for Rare Diseases and Beyond.

Authors:  N J Schork; K Nazor
Journal:  Adv Genet       Date:  2017-07-25       Impact factor: 1.944

4.  Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS).

Authors:  Harry Shamoon; David Center; Pamela Davis; Mendel Tuchman; Henry Ginsberg; Robert Califf; David Stephens; Thomas Mellman; Joseph Verbalis; Lee Nadler; Anantha Shekhar; Daniel Ford; Robert Rizza; Reza Shaker; Kathleen Brady; Barbara Murphy; Bruce Cronstein; Judith Hochman; Philip Greenland; Eric Orwoll; Lawrence Sinoway; Harry Greenberg; Rebecca Jackson; Barry Coller; Eric Topol; Lisa Guay-Woodford; Marschall Runge; Robert Clark; Don McClain; Harry Selker; Curtis Lowery; Steven Dubinett; Lars Berglund; Dan Cooper; Gary Firestein; S Clay Johnston; Julian Solway; James Heubi; Ronald Sokol; David Nelson; Larry Tobacman; Gary Rosenthal; Lauren Aaronson; Richard Barohn; Philip Kern; John Sullivan; Thomas Shanley; Bruce Blazar; Richard Larson; Garret FitzGerald; Steven Reis; Thomas Pearson; Thomas Buchanan; David McPherson; Allan Brasier; Robert Toto; Mary Disis; Marc Drezner; Gordon Bernard; John Clore; Bradley Evanoff; Julianne Imperato-McGinley; Robert Sherwin; Jill Pulley
Journal:  Clin Transl Sci       Date:  2012-03-27       Impact factor: 4.689

5.  Collaboration in Action: Measuring and Improving Contracting Performance in the University of California Contracting Network.

Authors:  Tam Tran; LeeAnna Bowman-Carpio; Nate Buscher; Jennifer J Ford; Erick Jenkins; Hillary Noll Kalay; Terry Nakazono; Helene Orescan; Rachael Sak; Irene Shin; Pamela Davidson
Journal:  Res Manag Rev       Date:  2017

6.  Evaluating various areas of process improvement in an effort to improve clinical research: discussions from the 2012 Clinical Translational Science Award (CTSA) Clinical Research Management workshop.

Authors:  Jane E Strasser; Philip A Cola; Daniel Rosenblum
Journal:  Clin Transl Sci       Date:  2013-04-19       Impact factor: 4.689

7.  Observational study of contracts processing at 29 CTSA sites.

Authors:  James Kiriakis; Nicholas Gaich; S Claiborne Johnston; Darlene Kitterman; Daniel Rosenblum; Libby Salberg; Adam Rifkind
Journal:  Clin Transl Sci       Date:  2013-06-10       Impact factor: 4.689

8.  Clinical research informatics: a conceptual perspective.

Authors:  Michael G Kahn; Chunhua Weng
Journal:  J Am Med Inform Assoc       Date:  2012-04-20       Impact factor: 4.497

9.  Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.

Authors:  Markus Krauss; Ute Hofmann; Clemens Schafmayer; Svitlana Igel; Reinhold Kerb; Jochen Hampe; Lars Kuepfer; Matthias Schwab; Jan Schlender; Christian Mueller; Mario Brosch; Witigo von Schoenfels; Wiebke Erhart; Andreas Schuppert; Michael Block; Elke Schaeffeler; Gabriele Boehmer; Linus Goerlitz; Jan Hoecker; Joerg Lippert
Journal:  NPJ Syst Biol Appl       Date:  2017-03-28

10.  Research Integrated Network of Systems (RINS): a virtual data warehouse for the acceleration of translational research.

Authors:  Wenjun He; Katie G Kirchoff; Royce R Sampson; Kimberly K McGhee; Andrew M Cates; Jihad S Obeid; Leslie A Lenert
Journal:  J Am Med Inform Assoc       Date:  2021-07-14       Impact factor: 4.497

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