PURPOSE: Purpose of the study is to reveal the changes of directional diffusion in cerebral white matter (WM) by normal aging. MATERIALS AND METHODS: Thirty-nine volunteers were recruited to examine the changes in the directional diffusion of cerebral white matter (WM) due to normal aging. RESULTS: No significant difference between the older and younger group (P>.05) was detected in the axial diffusivity (λ(ll)) of any of the regions of interest (ROI), while radial diffusivity (λ(perpendicular)) was significantly higher in the older group (P<.05) except for occipital lobe WM. CONCLUSION: λ(ll) and λ(perpendicular) may be used as in vivo markers that differentially and specifically reflect the WM changes of normal aging.
PURPOSE: Purpose of the study is to reveal the changes of directional diffusion in cerebral white matter (WM) by normal aging. MATERIALS AND METHODS: Thirty-nine volunteers were recruited to examine the changes in the directional diffusion of cerebral white matter (WM) due to normal aging. RESULTS: No significant difference between the older and younger group (P>.05) was detected in the axial diffusivity (λ(ll)) of any of the regions of interest (ROI), while radial diffusivity (λ(perpendicular)) was significantly higher in the older group (P<.05) except for occipital lobe WM. CONCLUSION: λ(ll) and λ(perpendicular) may be used as in vivo markers that differentially and specifically reflect the WM changes of normal aging.
Authors: Vincenza Castronovo; Paola Scifo; Antonella Castellano; Mark S Aloia; Antonella Iadanza; Sara Marelli; Stefano F Cappa; Luigi Ferini Strambi; Andrea Falini Journal: Sleep Date: 2014-09-01 Impact factor: 5.849
Authors: Melissa Lamar; Xiaohong Joe Zhou; Rebecca A Charlton; Douglas Dean; Deborah Little; Sean C Deoni Journal: Am J Geriatr Psychiatry Date: 2013-09-27 Impact factor: 4.105