Literature DB >> 22276650

Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp.

Gang Li1, Haiying Wang, Rongxiu Zhu, Lingmei Sun, Lining Wang, Ming Li, Yaoyao Li, Yongqing Liu, Zuntian Zhao, Hongxiang Lou.   

Abstract

Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.

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Year:  2012        PMID： 22276650     DOI： 10.1021/np200614h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Does the chemistry of fungal pigments demand the existence of photoactivated defense strategies in basidiomycetes?

Authors:  Bianka Siewert
Journal:  Photochem Photobiol Sci       Date:  2021-03-18       Impact factor: 3.982

2.  Effect of Isolation Conditions on Diversity of Endolichenic Fungal Communities from a Foliose Lichen, Parmotrema tinctorum.

Authors:  Ji Ho Yang; Seung-Yoon Oh; Wonyong Kim; Jung-Jae Woo; Hyeonjae Kim; Jae-Seoun Hur
Journal:  J Fungi (Basel)       Date:  2021-04-26

3.  Trapping toxins within lipid droplets is a resistance mechanism in fungi.

Authors:  Wenqiang Chang; Ming Zhang; Sha Zheng; Ying Li; Xiaobin Li; Wei Li; Gang Li; Zhaomin Lin; Zhiyu Xie; Zuntian Zhao; Hongxiang Lou
Journal:  Sci Rep       Date:  2015-10-14       Impact factor: 4.379

4.  A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.

Authors:  Yit-Heng Chooi; Mariano Jordi Muria-Gonzalez; Peter S Solomon
Journal:  Mycology       Date:  2014-06-24

5.  Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.

Authors:  Chao Yuan; Gang Ding; Hai-Ying Wang; Yu-Hua Guo; Hai Shang; Xiao-Jun Ma; Zhong-Mei Zou
Journal:  Biomed Res Int       Date:  2017-05-16       Impact factor: 3.411

Review 6.  Fungal perylenequinones.

Authors:  Afra Khiralla; Aisha Ohag Mohammed; Sakina Yagi
Journal:  Mycol Prog       Date:  2022-04-04       Impact factor: 2.538

7.  Secondary metabolites from the endolichenic fungus Ophiosphaerella korrae.

Authors:  Yue-Lan Li; Rong-Xiu Zhu; Gang Li; Ning-Ning Wang; Chun-Yu Liu; Zun-Tian Zhao; Hong-Xiang Lou
Journal:  RSC Adv       Date:  2019-01-31       Impact factor: 3.361

8.  New α-pyrones from an endophytic fungus, Hypoxylon investiens J2.

Authors:  Chao Yuan; Hong-Xia Yang; Yu-Hua Guo; Lin Fan; Ying-Bo Zhang; Gang Li
Journal:  RSC Adv       Date:  2019-09-02       Impact factor: 4.036

9.  An acetonic extract and secondary metabolites from the endolichenic fungus Nemania sp. EL006872 exhibit immune checkpoint inhibitory activity in lung cancer cell.

Authors:  Mücahit Varlı; Huong T Pham; Seong-Min Kim; İsa Taş; Chathurika D B Gamage; Rui Zhou; Sultan Pulat; So-Yeon Park; Nüzhet Cenk Sesal; Jae-Seoun Hur; Kyo Bin Kang; Hangun Kim
Journal:  Front Pharmacol       Date:  2022-09-08       Impact factor: 5.988

Review 10.  Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi.

Authors:  Tanja Thorskov Bladt; Jens Christian Frisvad; Peter Boldsen Knudsen; Thomas Ostenfeld Larsen
Journal:  Molecules       Date:  2013-09-13       Impact factor: 4.411
  10 in total

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