BACKGROUND: The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has been found to correlate with some diseases, tumor progression, and defective morphogenesis. Investigating the pattern of claudin expression during embryogenesis or in certain pathological conditions is necessary to begin disclosing the role of these proteins in health and disease. RESULTS: This study analyzed the expression of several claudins during mouse pancreas organogenesis and in pancreatic intraepithelial neoplasias of mouse and human origin. CONCLUSIONS: Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation.
BACKGROUND: The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has been found to correlate with some diseases, tumor progression, and defective morphogenesis. Investigating the pattern of claudin expression during embryogenesis or in certain pathological conditions is necessary to begin disclosing the role of these proteins in health and disease. RESULTS: This study analyzed the expression of several claudins during mouse pancreas organogenesis and in pancreatic intraepithelial neoplasias of mouse and human origin. CONCLUSIONS: Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation.
Authors: E R Wilcox; Q L Burton; S Naz; S Riazuddin; T N Smith; B Ploplis; I Belyantseva; T Ben-Yosef; N A Liburd; R J Morell; B Kachar; D K Wu; A J Griffith; S Riazuddin; T B Friedman Journal: Cell Date: 2001-01-12 Impact factor: 41.582
Authors: Anna De Benedetto; Nicholas M Rafaels; Laura Y McGirt; Andrei I Ivanov; Steve N Georas; Chris Cheadle; Alan E Berger; Kunzhong Zhang; Sadasivan Vidyasagar; Takeshi Yoshida; Mark Boguniewicz; Tissa Hata; Lynda C Schneider; Jon M Hanifin; Richard L Gallo; Natalija Novak; Stephan Weidinger; Terri H Beaty; Donald Y M Leung; Kathleen C Barnes; Lisa A Beck Journal: J Allergy Clin Immunol Date: 2010-12-15 Impact factor: 10.793
Authors: R H Hruban; N V Adsay; J Albores-Saavedra; C Compton; E S Garrett; S N Goodman; S E Kern; D S Klimstra; G Klöppel; D S Longnecker; J Lüttges; G J Offerhaus Journal: Am J Surg Pathol Date: 2001-05 Impact factor: 6.394
Authors: Yoshiya Kawaguchi; Bonnie Cooper; Maureen Gannon; Michael Ray; Raymond J MacDonald; Christopher V E Wright Journal: Nat Genet Date: 2002-08-19 Impact factor: 38.330
Authors: Kevin C Ray; Kayla M Bell; Jingbo Yan; Guoqiang Gu; Christine H Chung; M Kay Washington; Anna L Means Journal: PLoS One Date: 2011-02-02 Impact factor: 3.240
Authors: Anne-Christine Hick; Jonathan M van Eyll; Sabine Cordi; Céline Forez; Lara Passante; Hiroshi Kohara; Takashi Nagasawa; Pierre Vanderhaeghen; Pierre J Courtoy; Guy G Rousseau; Frédéric P Lemaigre; Christophe E Pierreux Journal: BMC Dev Biol Date: 2009-12-14 Impact factor: 1.978
Authors: Janel L Kopp; Claire L Dubois; David F Schaeffer; Atefeh Samani; Farnaz Taghizadeh; Robert W Cowan; Andrew D Rhim; Bangyan L Stiles; Mark Valasek; Maike Sander Journal: Gastroenterology Date: 2017-12-19 Impact factor: 22.682
Authors: Nathan M Krah; Jean-Paul De La O; Galvin H Swift; Chinh Q Hoang; Spencer G Willet; Fong Chen Pan; Gabriela M Cash; Mary P Bronner; Christopher Ve Wright; Raymond J MacDonald; L Charles Murtaugh Journal: Elife Date: 2015-07-07 Impact factor: 8.140
Authors: Yiannis Drosos; Geoffrey Neale; Jianming Ye; Leena Paul; Emin Kuliyev; Anirban Maitra; Anna L Means; M Kay Washington; Jerold Rehg; David B Finkelstein; Beatriz Sosa-Pineda Journal: Neoplasia Date: 2016-03 Impact factor: 5.715
Authors: Yiannis Drosos; David Escobar; Ming-Yi Chiang; Kathryn Roys; Virginia Valentine; Marc B Valentine; Jerold E Rehg; Vaibhav Sahai; Lesa A Begley; Jianming Ye; Leena Paul; Peter J McKinnon; Beatriz Sosa-Pineda Journal: Sci Rep Date: 2017-09-11 Impact factor: 4.379