| Literature DB >> 22274704 |
Junko Hashida1, Megumi Niitsuma, Masato Iwatsuki, Mihoko Mori, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Atsuko Matsumoto, Ismet Ara, Yoko Takahashi, Haruki Yamada, Kazuhiko Otoguro, Kazuro Shiomi, Satoshi Omura.
Abstract
Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC(50) values of 0.40 and 3.30 μg ml(-1), respectively.Entities:
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Year: 2012 PMID： 22274704 DOI： 10.1038/ja.2011.139
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649