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Literature DB >> 2227371

Assessing the effect of multiple linkage tests in complex diseases.

F Clerget-Darpoux¹, M C Babron, C Bonaïti-Pellié.
1. INSERM U155, Paris, France.

Abstract

The significance of a lod score value of 3 is very difficult to assess in linkage studies between a genetic marker and a complex disease. One reason is that multiple tests may have been performed, voluntarily or otherwise. For the same disease, linkage may be tested by different laboratories with several markers under various genetic models and diagnostic schemes for the disease. In such a case, we show that the probability of getting a lod score value of 3 under independent transmission of the disease and the marker may be not negligible.

Mesh：

Substances：
Genetic Markers

Year: 1990 PMID： 2227371 DOI： 10.1002/gepi.1370070403

Source DB: PubMed Journal: Genet Epidemiol ISSN： 0741-0395 Impact factor: 2.135

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Cited

12 in total

1. Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization.

Authors: K Strauch; R Fimmers; T Kurz; K A Deichmann; T F Wienker; M P Baur
Journal: Am J Hum Genet Date: 2000-05-04 Impact factor: 11.025

10. Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region.

Authors: W P Whitehouse; M Rees; D Curtis; A Sundqvist; K Parker; E Chung; D Baralle; R M Gardiner
Journal: Am J Hum Genet Date: 1993-09 Impact factor: 11.025

Assessing the effect of multiple linkage tests in complex diseases.

1. Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization.

2. Status of the search for a major genetic locus for affective disorder in the Old Order Amish.

3. Bayesian analysis of linkage between genetic markers and quantitative trait loci. I. Prior knowledge.

4. Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study.

5. Distribution of lod scores under uncertain mode of inheritance.

6. Conclusions of segregation analysis for family data generated under two-locus models.

7. Two-locus models of disease: comparison of likelihood and nonparametric linkage methods.

8. No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region.

9. Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis.

10. Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region.