Jessica Bon1. 1. Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. bonjm@upmc.edu
Abstract
PURPOSE OF REVIEW: Several large epidemiologic studies have shown an association between chronic obstructive pulmonary disease (COPD) and osteoporosis. Recent studies have further implied an emphysema-specific association with low bone mineral density independent of obstruction severity. RECENT FINDINGS: This review will outline the studies demonstrating an independent association between radiographic emphysema and decreased bone mineral density and will discuss potential disease mechanisms, including systemic inflammation and immune-mediated factors, linking these disease processes. SUMMARY: Radiographic emphysema should be considered an independent risk factor in studies examining the mechanisms underlying COPD-related bone loss. Future research focused on the relationship between emphysema and low bone mineral density could provide mechanistic insight and result in the development of targeted therapies designed to halt progression of both disease processes.
PURPOSE OF REVIEW: Several large epidemiologic studies have shown an association between chronic obstructive pulmonary disease (COPD) and osteoporosis. Recent studies have further implied an emphysema-specific association with low bone mineral density independent of obstruction severity. RECENT FINDINGS: This review will outline the studies demonstrating an independent association between radiographic emphysema and decreased bone mineral density and will discuss potential disease mechanisms, including systemic inflammation and immune-mediated factors, linking these disease processes. SUMMARY: Radiographic emphysema should be considered an independent risk factor in studies examining the mechanisms underlying COPD-related bone loss. Future research focused on the relationship between emphysema and low bone mineral density could provide mechanistic insight and result in the development of targeted therapies designed to halt progression of both disease processes.
Authors: Elisabeth A P M Romme; Piet Geusens; Willem F Lems; Erica P A Rutten; Frank W J M Smeenk; Joop P W van den Bergh; Peter ThW van Hal; Emiel F M Wouters Journal: Respir Res Date: 2015-03-07
Authors: Elisabeth A P M Romme; David A McAllister; John T Murchison; Edwin J R Van Beek; George S Petrides; Cameron O S Price; Erica P A Rutten; Frank W J M Smeenk; Emiel F M Wouters; William MacNee Journal: Respir Res Date: 2013-11-19
Authors: Mona Ali Fouda; Esam Hamad Alhamad; Mohammed Saleh Al-Hajjaj; Shaffi Ahmed Shaik; Ahmad Amer Alboukai; Feisal Abdulla Al-Kassimi Journal: Ann Thorac Med Date: 2017 Apr-Jun Impact factor: 2.219