Literature DB >> 22273253

Facile synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via Brønsted acid catalyzed sp3 C-H functionalization.

Rui Niu1, Jian Xiao, Tao Liang, Xingwei Li.   

Abstract

Brønsted acid catalyzed functionalization of sp(3) C-H bonds in 2-methyl azaarenes has been achieved in the reaction with isatins. This method provides facile synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step in moderate to good yields.
© 2012 American Chemical Society

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Year:  2012        PMID: 22273253     DOI: 10.1021/ol2030982

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

1.  Preparation of Aryl-Susbstituted 2-Oxyindoles by Superelectrophilic Chemistry.

Authors:  Rajasekhar Reddy Naredla; Erum K Raja; Douglas A Klumpp
Journal:  Tetrahedron Lett       Date:  2013-06-19       Impact factor: 2.415

2.  Discovery of ML326: The first sub-micromolar, selective M5 PAM.

Authors:  Patrick R Gentry; Thomas M Bridges; Atin Lamsal; Paige N Vinson; Emery Smith; Peter Chase; Peter S Hodder; Julie L Engers; Colleen M Niswender; J Scott Daniels; P Jeffrey Conn; Michael R Wood; Craig W Lindsley
Journal:  Bioorg Med Chem Lett       Date:  2013-03-16       Impact factor: 2.823

3.  Acetic Acid Promoted Redox Annulations with Dual C-H Functionalization.

Authors:  Zhengbo Zhu; Daniel Seidel
Journal:  Org Lett       Date:  2017-05-16       Impact factor: 6.005

  3 in total

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