OBJECTIVE: This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors. METHOD: The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0-12) and donated cheek cells for 5-HTTLPR and rs25531 genotyping. RESULTS: Women carrying a lower expressing allele (i.e., L(G) or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating problems (gender × genotype × trauma interaction, p = .006). DISCUSSION: These results are consistent with findings that the lower expressing alleles of the SLC6A4 promoter are associated with increased sensitivity to the negative impact of childhood stressors on adult behavioral outcomes.
OBJECTIVE: This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors. METHOD: The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0-12) and donated cheek cells for 5-HTTLPR and rs25531 genotyping. RESULTS:Women carrying a lower expressing allele (i.e., L(G) or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating problems (gender × genotype × trauma interaction, p = .006). DISCUSSION: These results are consistent with findings that the lower expressing alleles of the SLC6A4 promoter are associated with increased sensitivity to the negative impact of childhood stressors on adult behavioral outcomes.
Authors: P Monteleone; P Santonastaso; A Tortorella; A Favaro; M Fabrazzo; E Castaldo; L Caregaro; A Fuschino; M Maj Journal: Mol Psychiatry Date: 2005-08 Impact factor: 15.992
Authors: D Erritzoe; V G Frokjaer; M T Haahr; J Kalbitzer; C Svarer; K K Holst; D L Hansen; T L Jernigan; S Lehel; G M Knudsen Journal: Neuroimage Date: 2010-04-09 Impact factor: 6.556
Authors: Dennis L Murphy; Meredith A Fox; Kiara R Timpano; Pablo R Moya; Renee Ren-Patterson; Anne M Andrews; Andrew Holmes; Klaus-Peter Lesch; Jens R Wendland Journal: Neuropharmacology Date: 2008-09-11 Impact factor: 5.250
Authors: Elisabeth A H von dem Hagen; Luca Passamonti; Sarah Nutland; Jennifer Sambrook; Andrew J Calder Journal: Neuropsychologia Date: 2010-12-15 Impact factor: 3.139
Authors: Evangelia Saleptsi; Dana Bichescu; Brigitte Rockstroh; Frank Neuner; Margarete Schauer; Karl Studer; Klaus Hoffmann; Thomas Elbert Journal: BMC Psychiatry Date: 2004-11-26 Impact factor: 3.630
Authors: Jennifer L Bakalar; Lisa M Shank; Anna Vannucci; Rachel M Radin; Marian Tanofsky-Kraff Journal: Curr Psychiatry Rep Date: 2015-06 Impact factor: 5.285
Authors: Vanja Rozenblat; Deborah Ong; Matthew Fuller-Tyszkiewicz; Kirsti Akkermann; David Collier; Rutger C M E Engels; Fernando Fernandez-Aranda; Jaanus Harro; Judith R Homberg; Andreas Karwautz; Evelyn Kiive; Kelly L Klump; Christine L Larson; Sarah E Racine; Jodie Richardson; Howard Steiger; Scott F Stoltenberg; Tatjana van Strien; Gudrun Wagner; Janet Treasure; Isabel Krug Journal: J Psychiatr Res Date: 2016-09-24 Impact factor: 4.791