BACKGROUND:Botulinum neurotoxin typeA (BTXA) offers a minimally invasive approach for the treatment of facial rhytides and has been well accepted by male patients. However, few comparative studies about the efficacy of the different BTXA preparations in this emerging group of patients are available. OBJECTIVE: To access the efficacy of four BTXA preparations in the treatment of hyperdynamic forehead lines in men. METHODS:Twelve male patients with a mean age of 30.5±5.26 years, with moderate or severe hyperdynamic forehead lines on a facial wrinkle scale (FWS), were involved in the study. Using an intra-individual controlled study design, either 17 mouse units (m.U) of Botox, Prosigne, and Xeomin or 51 Speywood units (s.U) of Dysport were applied to each side of a patient's forehead. Subjects with absent or mild forehead lines were considered responders. Study evaluations were performed monthly up to day 150. RESULTS: All patients responded in a side-to-side evaluation and no asymmetries or differences in the degree of reduction of hyperdynamic forehead lines were noted at day 30 and day 60 (P=0.340). Analysis of all combined forehead sides treated with a given BTXA did not show statistically significant differences in terms of maintenance of improvement between different BTXA preparations at day 150 (P=0.528). CONCLUSION: The data obtained in this study revealed a similar effectiveness of the BTXA preparations evaluated in the treatment of hyperdynamic forehead lines in men, when considering a dose-ratio of 1 m.U of Botox, Xeomin or Prosigne to 3 s.U of Dysport.
RCT Entities:
BACKGROUND: Botulinum neurotoxin type A (BTXA) offers a minimally invasive approach for the treatment of facial rhytides and has been well accepted by male patients. However, few comparative studies about the efficacy of the different BTXA preparations in this emerging group of patients are available. OBJECTIVE: To access the efficacy of four BTXA preparations in the treatment of hyperdynamic forehead lines in men. METHODS: Twelve male patients with a mean age of 30.5±5.26 years, with moderate or severe hyperdynamic forehead lines on a facial wrinkle scale (FWS), were involved in the study. Using an intra-individual controlled study design, either 17 mouse units (m.U) of Botox, Prosigne, and Xeomin or 51 Speywood units (s.U) of Dysport were applied to each side of a patient's forehead. Subjects with absent or mild forehead lines were considered responders. Study evaluations were performed monthly up to day 150. RESULTS: All patients responded in a side-to-side evaluation and no asymmetries or differences in the degree of reduction of hyperdynamic forehead lines were noted at day 30 and day 60 (P=0.340). Analysis of all combined forehead sides treated with a given BTXA did not show statistically significant differences in terms of maintenance of improvement between different BTXA preparations at day 150 (P=0.528). CONCLUSION: The data obtained in this study revealed a similar effectiveness of the BTXA preparations evaluated in the treatment of hyperdynamic forehead lines in men, when considering a dose-ratio of 1 m.U of Botox, Xeomin or Prosigne to 3 s.U of Dysport.
Authors: Mark Nestor; Joel L Cohen; Marina Landau; Said Hilton; Andreas Nikolis; Syed Haq; Maurizio Viel; Bill Andriopoulos; Inna Prygova; Keith Foster; Alessio Redaelli; Philippe Picaut Journal: J Clin Aesthet Dermatol Date: 2020-12-01
Authors: Welf Prager; Jürgen Huber-Vorländer; A Ziah Taufig; Matthias Imhof; Ulrich Kühne; Ruth Weissberg; Lars-Peter Kuhr; Volker Rippmann; Wolfgang G Philipp-Dormston; Thomas M Proebstle; Claudia Roth; Martina Kerscher; Claudius Ulmann; Tatjana Pavicic Journal: Clin Cosmet Investig Dermatol Date: 2012-06-08