| Literature DB >> 22269942 |
Shengtao Zhou1, Yuhua Li, Fuqiang Huang, Boya Zhang, Tao Yi, Zhengyu Li, Hong Luo, Xiang He, Qian Zhong, Ce Bian, Xiaojuan Lin, Xiaorong Qi, Ping Liu, Canhua Huang, Xia Zhao, Yuquan Wei.
Abstract
Herein we present a novel molecular mechanism of the antitumor effects of live-attenuated measles virus (MV) vaccine in ovarian cancer. Using a 2-DE/MS-based comparative proteomics strategy, we identified 17 proteins differentially expressed in live-attenuated MV vaccine-treated SKOV-3 ovarian cancer cells, including oxidative stress-associated enzymes and cell contact-related proteins, which indicated that live-attenuated MV vaccine could induce aberrant ROS activation. It further mediated epigenetic silencing of E-cadherin via upregulating DNMT3a that conferred both cell-cell and cell-matrix contact loss and apoptosis of ovarian cancer cells. This process could be reversed through ROS inhibition. Our study lays the theoretical foundation for the clinical application of live-attenuated MV vaccine as a potential oncotherapeutic agent for ovarian cancer treatment.Entities:
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Year: 2011 PMID： 22269942 DOI： 10.1016/j.canlet.2011.10.038
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679