BACKGROUND: This is the first study that aimed to determine the efficacy and safety of concurrent chemoradiation with weekly cisplatin ± celecoxib 100 mg twice daily in locally advanced undifferentiated nasopharyngeal carcinoma. MATERIALS AND METHODS:Eligible patients had newly diagnosed locally advanced (T3-T4, and/or N2-N3, M0) undifferentiated nasopharyngeal carcinoma, no prior therapy, Karnofsky performance status ≥ 70, and normal organ function. The patients were assigned to receive 7 weeks concurrent chemoradiation (70 Gy) with weekly cisplatin 30 mg/m 2 with either celecoxib 100 mg twice daily, (study group, n = 26) or placebo (control group, n = 27) followed by adjuvant combined chemotherapy with cisplatin 70 mg/m 2 on day 1 plus 5-fluorouracil 750 mg/m 2 /d with 8-h infusion on days 1-3, 3-weekly for 3 cycles. RESULTS:Overall clinical response rate was 100% in both groups. Complete and partial clinical response rates were 64% and 36% in the study group and 44% and 56% in the control group, respectively (P > 0.25). The addition of celecoxib to concurrent chemoradiation was associated with improved 2-year locoregional control rate from 84% to 100% (P = 0.039). CONCLUSIONS: The addition of celecoxib 100 mg twice daily to concurrent chemoradiation improved 2-year locoregional control rate.
RCT Entities:
BACKGROUND: This is the first study that aimed to determine the efficacy and safety of concurrent chemoradiation with weekly cisplatin ± celecoxib 100 mg twice daily in locally advanced undifferentiated nasopharyngeal carcinoma. MATERIALS AND METHODS: Eligible patients had newly diagnosed locally advanced (T3-T4, and/or N2-N3, M0) undifferentiated nasopharyngeal carcinoma, no prior therapy, Karnofsky performance status ≥ 70, and normal organ function. The patients were assigned to receive 7 weeks concurrent chemoradiation (70 Gy) with weekly cisplatin 30 mg/m 2 with either celecoxib 100 mg twice daily, (study group, n = 26) or placebo (control group, n = 27) followed by adjuvant combined chemotherapy with cisplatin 70 mg/m 2 on day 1 plus 5-fluorouracil 750 mg/m 2 /d with 8-h infusion on days 1-3, 3-weekly for 3 cycles. RESULTS: Overall clinical response rate was 100% in both groups. Complete and partial clinical response rates were 64% and 36% in the study group and 44% and 56% in the control group, respectively (P > 0.25). The addition of celecoxib to concurrent chemoradiation was associated with improved 2-year locoregional control rate from 84% to 100% (P = 0.039). CONCLUSIONS: The addition of celecoxib 100 mg twice daily to concurrent chemoradiation improved 2-year locoregional control rate.
Authors: Corinne M Doll; Kathryn Winter; David K Gaffney; Janice K Ryu; Anuja Jhingran; Adam P Dicker; Joanne B Weidhaas; Brigitte E Miller; Anthony M Magliocco Journal: Int J Gynecol Cancer Date: 2013-01 Impact factor: 3.437
Authors: Ravi P Sahu; Jesus A Ocana; Kathleen A Harrison; Matheus Ferracini; Christopher E Touloukian; Mohammed Al-Hassani; Louis Sun; Mathew Loesch; Robert C Murphy; Sandra K Althouse; Susan M Perkins; Paul J Speicher; Douglas S Tyler; Raymond L Konger; Jeffrey B Travers Journal: Cancer Res Date: 2014-10-10 Impact factor: 12.701
Authors: Ravi P Sahu; Kathleen A Harrison; Jonathan Weyerbacher; Robert C Murphy; Raymond L Konger; Joy Elizabeth Garrett; Helen Jan Chin-Sinex; Michael Edward Johnston; Joseph R Dynlacht; Marc Mendonca; Kevin McMullen; Gengxin Li; Dan F Spandau; Jeffrey B Travers Journal: Oncotarget Date: 2016-04-12