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Literature DB >> 22268295

Role of epithelial stem/progenitor cells in mammary cancer.

Abstract

Both mouse and human mammary glands contain stem/progenitor functional hierarchies that are maintained through the entire life span of the animal. Cells with such functional capacities are potential candidates for tumorigenesis as they are long lived, multipotent, and self-renewing. Using the mouse as a model, this review will discuss what is known about the mammary stem/progenitor hierarchy, the evidence that particular progenitor functions are susceptible to tumorigenic stimuli, how these findings in mice are relevant to the disease in humans, and the role of the local microenvironment in controlling tumorigenesis.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 22268295 PMCID： PMC6043825 DOI： 10.3727/105221611x13176664479368

Source DB: PubMed Journal: Gene Expr ISSN： 1052-2166

43 in total

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Authors: K B DEOME; L J FAULKIN; H A BERN; P B BLAIR
Journal: Cancer Res Date: 1959-06 Impact factor: 12.701

2. Regulation of growth and spacing of gland elements in the mammary fat pad of the C3H mouse.

Authors: L J FAULKIN; K B DEOME
Journal: J Natl Cancer Inst Date: 1960-04 Impact factor: 13.506

3. The mammary microenvironment alters the differentiation repertoire of neural stem cells.

Authors: Brian W Booth; David L Mack; Andreas Androutsellis-Theotokis; Ronald D G McKay; Corinne A Boulanger; Gilbert H Smith
Journal: Proc Natl Acad Sci U S A Date: 2008-09-22 Impact factor: 11.205

4. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.

Authors: Kay-Uwe Wagner; Andrea Krempler; Yongyue Qi; KyungRan Park; MaLinda D Henry; Aleata A Triplett; Gregory Riedlinger; Edmund B Rucker III; Lothar Hennighausen
Journal: Mol Cell Biol Date: 2003-01 Impact factor: 4.272

5. Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor.

Authors: R D Bruno; C A Boulanger; G H Smith
Journal: Oncogene Date: 2011-06-13 Impact factor: 9.867

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Authors: Y C Tsai; Y Lu; P W Nichols; G Zlotnikov; P A Jones; H S Smith
Journal: Cancer Res Date: 1996-01-15 Impact factor: 12.701

7. Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population.

Authors: E C Kordon; R A McKnight; C Jhappan; L Hennighausen; G Merlino; G H Smith
Journal: Dev Biol Date: 1995-03 Impact factor: 3.582

8. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis.

Authors: Jonathan M Shillingford; Keiko Miyoshi; Michael Flagella; Gary E Shull; Lothar Hennighausen
Journal: Mol Endocrinol Date: 2002-06

9. Quantitative studies of ductal versus alveolar differentiation from rat mammary clonogens.

Authors: K Kamiya; M N Gould; K H Clifton
Journal: Proc Soc Exp Biol Med Date: 1998-12

10. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.

Authors: Peter Eirew; John Stingl; Afshin Raouf; Gulisa Turashvili; Samuel Aparicio; Joanne T Emerman; Connie J Eaves
Journal: Nat Med Date: 2008-11-23 Impact factor: 53.440

5 in total

1. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.

Authors: Lisa M Arendt; Patricia J Keller; Adam Skibinski; Kevin Goncalves; Stephen P Naber; Rachel J Buchsbaum; Hannah Gilmore; Steven E Come; Charlotte Kuperwasser
Journal: Breast Cancer Res Date: 2014-10-15 Impact factor: 6.466