Literature DB >> 2226823

Luminol enhanced chemiluminescence of the perfused rat heart during ischemia and reperfusion.

C Kumar1, M Okuda, I Ikai, B Chance.   

Abstract

We show that the production of Luminol reactive oxygen radicals in the perfused rat heart under ischemia and reperfusion can be monitored continuously by measuring the chemiluminescence of Luminol-perfused hearts. Luminol did not affect the monitored physiological parameters of the hearts. Chemiluminescence increased during ischemia and reperfusion. Superoxide dismutase treatment of the heart before ischemia, but not catalase, abolished these increases.

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Year:  1990        PMID： 2226823     DOI： 10.1016/0014-5793(90)80463-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Uncoupling of mitochondrial oxidative phosphorylation alters lipid peroxidation-derived free radical production but not recovery of postischemic rat hearts and post-hypoxic endothelial cells.

Authors:  I E Blasig; B F Dickens; W B Weglicki; J H Kramer
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

2.  Postischemic injury in isolated rat hearts is not aggravated by prior depletion of myocardial glutathione.

Authors:  R J Verbunt; W G Van Dockum; E M Bastiaanse; J M Egas; A Van der Laarse
Journal:  Mol Cell Biochem       Date:  1996-03-09       Impact factor: 3.396

3.  Clastogenic factors as potential biomarkers of increased superoxide production.

Authors:  Ingrid Emerit
Journal:  Biomark Insights       Date:  2007-12-11

4.  Chemiluminescent measurement of increased free radical formation after ischemia/reperfusion. Mechanisms of free radical formation in the liver.

Authors:  F A Nunes; C Kumar; B Chance; C A Brass
Journal:  Dig Dis Sci       Date:  1995-05       Impact factor: 3.199
  4 in total

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