Literature DB >> 2226783

Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones.

E Fink1, C Hehlein-Fink, M Eulitz.   

Abstract

The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone beta-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.

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Year:  1990        PMID： 2226783     DOI： 10.1016/0014-5793(90)81273-q

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  A male reproduction-related Kazal-type peptidase inhibitor gene in the prawn, Macrobrachium rosenbergii: molecular characterization and expression patterns.

Authors:  Jun-Xia Cao; Jie-Qiong Dai; Zhong-Min Dai; Guo-Li Yin; Wei-Jun Yang
Journal:  Mar Biotechnol (NY)       Date:  2006-09-15       Impact factor: 3.619

2.  The Drosophila melanogaster seminal fluid protein Acp62F is a protease inhibitor that is toxic upon ectopic expression.

Authors:  Oliver Lung; Uyen Tram; Casey M Finnerty; Marcie A Eipper-Mains; John M Kalb; Mariana F Wolfner
Journal:  Genetics       Date:  2002-01       Impact factor: 4.562

3.  Proteomic analysis of heparin-binding proteins from human seminal plasma: a step towards identification of molecular markers of male fertility.

Authors:  Vijay Kumar; Md Imtaiyaz Hassan; Anil Kumar Tomar; Tara Kashav; Jaya Nautiyal; Sarman Singh; Tej P Singh; Savita Yadav
Journal:  J Biosci       Date:  2009-12       Impact factor: 1.826

4.  Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.

Authors:  Li Ma; Heguo Yu; Zimei Ni; Shuanggang Hu; Wubin Ma; Chen Chu; Qiang Liu; Yonglian Zhang
Journal:  J Biol Chem       Date:  2013-02-19       Impact factor: 5.157

5.  Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes.

Authors:  Boyeon Lee; Inju Park; Sora Jin; Heejin Choi; Jun Tae Kwon; Jihye Kim; Juri Jeong; Byung-Nam Cho; Edward M Eddy; Chunghee Cho
Journal:  J Biol Chem       Date:  2011-06-24       Impact factor: 5.157
  5 in total

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