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Literature DB >> 22267085

Endocytosis by Numb breaks Notch symmetry at cytokinesis.

Lydie Couturier¹, Nicolas Vodovar, François Schweisguth.

Abstract

Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.

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Year: 2012 PMID： 22267085 DOI： 10.1038/ncb2419

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

36 in total

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5. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.

Authors: M S Rhyu; L Y Jan; Y N Jan
Journal: Cell Date: 1994-02-11 Impact factor: 41.582

6. Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.

Authors: Fabrice Roegiers; Lily Yeh Jan; Yuh Nung Jan
Journal: Mol Biol Cell Date: 2005-05-18 Impact factor: 4.138

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Authors: Najate Benhra; Sylvie Lallet; Mathieu Cotton; Stéphanie Le Bras; Aurore Dussert; Roland Le Borgne
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8. Direct observation of individual endogenous protein complexes in situ by proximity ligation.

Authors: Ola Söderberg; Mats Gullberg; Malin Jarvius; Karin Ridderstråle; Karl-Johan Leuchowius; Jonas Jarvius; Kenneth Wester; Per Hydbring; Fuad Bahram; Lars-Gunnar Larsson; Ulf Landegren
Journal: Nat Methods Date: 2006-10-29 Impact factor: 28.547

9. Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division.

Authors: José-Eduardo Gomes; Maria Corado; François Schweisguth
Journal: PLoS One Date: 2009-02-13 Impact factor: 3.240

10. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.

Authors: Qin Shen; Weimin Zhong; Yuh Nung Jan; Sally Temple
Journal: Development Date: 2002-10 Impact factor: 6.868

55 in total

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Journal: J Biol Chem Date: 2012-07-09 Impact factor: 5.157

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6. Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.

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Journal: J Biol Chem Date: 2012-04-03 Impact factor: 5.157

7. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.

Authors: Marika Sjöqvist; Daniel Antfolk; Saima Ferraris; Vilma Rraklli; Cecilia Haga; Christian Antila; Anders Mutvei; Susumu Y Imanishi; Johan Holmberg; Shaobo Jin; John E Eriksson; Urban Lendahl; Cecilia Sahlgren
Journal: Cell Res Date: 2014-03-25 Impact factor: 25.617

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Review 9. Satellite Cells in Muscular Dystrophy - Lost in Polarity.

Authors: Natasha C Chang; Fabien P Chevalier; Michael A Rudnicki
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10. Antibody Uptake Assay in the Embryonic Zebrafish Forebrain to Study Notch Signaling Dynamics in Neural Progenitor Cells In Vivo.

Authors: Kai Tong; Mahendra Wagle; Su Guo
Journal: Methods Mol Biol Date: 2019