BACKGROUND: There are limited data on the role of laser-assisted surgery for early glottic cancer in elderly patients. METHODS: This retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (>65 years old) treated with CO(2) laser surgery. RESULTS: The overall and disease-specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease-free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (p = .01) and the status of the surgical margins (p = .002); on multivariate analysis, only the latter remained prognostically significant vis-à-vis the DFS (p = .002). CONCLUSIONS: Even in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment.
BACKGROUND: There are limited data on the role of laser-assisted surgery for early glottic cancer in elderly patients. METHODS: This retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (>65 years old) treated with CO(2) laser surgery. RESULTS: The overall and disease-specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease-free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (p = .01) and the status of the surgical margins (p = .002); on multivariate analysis, only the latter remained prognostically significant vis-à-vis the DFS (p = .002). CONCLUSIONS: Even in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment.
Authors: Changseok Lee; David Forner; Christopher W Noel; Victoria Taylor; Colin MacKay; Matthew H Rigby; Martin Corsten; Jonathan R Trites; S Mark Taylor Journal: OTO Open Date: 2021-09-29
Authors: Alberto Paderno; Davide Lancini; Paolo Bosio; Francesca Del Bon; Milena Fior; Giulia Berretti; Marco Alparone; Alberto Deganello; Giorgio Peretti; Cesare Piazza Journal: Laryngoscope Date: 2021-07-07 Impact factor: 2.970