| Literature DB >> 22266736 |
Kyoungjin Shin1, Jungwook Chin, Dongyup Hahn, Jaehwan Lee, Hoosang Hwang, Dong Hwan Won, Jungyeob Ham, Hyukjae Choi, Eunsoo Kang, Hiyoung Kim, Moon Kyeong Ju, Sang-Jip Nam, Heonjoong Kang.
Abstract
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC(50)'s 14 and 15μM. Copyright ÂEntities:
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Year: 2012 PMID： 22266736 DOI： 10.1016/j.steroids.2011.12.027
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668