Literature DB >> 2226646

Effect of TGF-beta 1, TGF-beta 2, and bFGF on chick cartilage and muscle cell differentiation.

J N Schofield1, L Wolpert.   

Abstract

In insulin containing defined medium TGF-beta 1, TGF-beta 2, and bFGF all stimulate chondrogenic differentiation in high-density micromass cultures of distal limb bud mesenchyme cells of chick embryos. In addition bFGF inhibits myogenic differentiation, while TGF-beta 1 and TGF-beta 2 appear to have no effect. TGF-beta 1 and bFGF together act additively to enhance chondrogenesis, while TGF-beta blocks the bFGF inhibitory action on myoblasts, thus allowing them to differentiate. In the absence of insulin, the inhibitory effect of bFGF on muscle cell differentiation is reduced; cartilage differentiation in the presence of the above growth factors is also slightly reduced.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2226646     DOI： 10.1016/0014-4827(90)90048-f

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  9 in total

Review 1.  Mechanical modulation of osteochondroprogenitor cell fate.

Authors:  Melissa L Knothe Tate; Thomas D Falls; Sarah H McBride; Radhika Atit; Ulf R Knothe
Journal:  Int J Biochem Cell Biol       Date:  2008-05-24       Impact factor: 5.085

2.  Smad7 promotes and enhances skeletal muscle differentiation.

Authors:  Helen D Kollias; Robert L S Perry; Tetsuaki Miyake; Arif Aziz; John C McDermott
Journal:  Mol Cell Biol       Date:  2006-08       Impact factor: 4.272

3.  Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo.

Authors:  Patrick Orth; Gunter Kaul; Magali Cucchiarini; David Zurakowski; Michael D Menger; Dieter Kohn; Henning Madry
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-02-25       Impact factor: 4.342

4.  Staurosporine induces chondrogenesis of chick embryo wing bud mesenchyme in monolayer cultures through canonical and non-canonical TGF-β pathways.

Authors:  Hyoin Kim; Kyungmin Kei; Jong Kyung Sonn
Journal:  In Vitro Cell Dev Biol Anim       Date:  2015-10-01       Impact factor: 2.416

5.  Parathyroid hormone and transforming growth factor-beta1 coregulate chondrocyte differentiation in vitro.

Authors:  E Nasatzky; E Azran; D D Dean; B D Boyan; Z Schwartz
Journal:  Endocrine       Date:  2000-12       Impact factor: 3.633

6.  Modification of the phalangeal pattern of the digits in the chick embryo leg bud by local microinjection of RA, staurosporin and TGF beta's.

Authors:  D Macias; Y Gañan; J M Hurlé
Journal:  Anat Embryol (Berl)       Date:  1993-08

7.  Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme.

Authors:  Carlos I Lorda-Diez; Juan A Montero; Carmen Martinez-Cue; Juan A Garcia-Porrero; Juan M Hurle
Journal:  J Biol Chem       Date:  2009-08-28       Impact factor: 5.157

8.  TGF-β Stimulates Endochondral Differentiation after Denervation.

Authors:  Ye Li; Austin Y Tian; Jennifer Ophene; Mason Y Tian; Zhenjiang Yao; Sidong Chen; Hongwei Li; Xiaoyan Sun; Hongyan Du
Journal:  Int J Med Sci       Date:  2017-04-08       Impact factor: 3.738

9.  TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation.

Authors:  Christian G Pfeifer; Alexandra Karl; Maximilian Kerschbaum; Arne Berner; Siegmund Lang; Rupert Schupfner; Matthias Koch; Peter Angele; Michael Nerlich; Michael B Mueller
Journal:  Int J Stem Cells       Date:  2019-03-30       Impact factor: 2.500
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.