Literature DB >> 22266285

Therapeutic potential of Liver Receptor Homolog-1 modulators.

Kyren A Lazarus1, Dhilushi Wijayakumara, Ashwini L Chand, Evan R Simpson, Colin D Clyne.   

Abstract

Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22266285     DOI： 10.1016/j.jsbmb.2011.12.017

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  22 in total

1.  The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Authors:  Michael A Hale; Galvin H Swift; Chinh Q Hoang; Tye G Deering; Toshi Masui; Youn-Kyoung Lee; Jumin Xue; Raymond J MacDonald
Journal:  Development       Date:  2014-07-25       Impact factor: 6.868

Review 2.  Nuclear receptors and pathogenesis of pancreatic cancer.

Authors:  Simone Polvani; Mirko Tarocchi; Sara Tempesti; Andrea Galli
Journal:  World J Gastroenterol       Date:  2014-09-14       Impact factor: 5.742

3.  LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression.

Authors:  S Bianco; M Jangal; D Garneau; N Gévry
Journal:  Oncogene       Date:  2014-12-01       Impact factor: 9.867

4.  Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.

Authors:  James R Bayrer; Sridevi Mukkamala; Elena P Sablin; Paul Webb; Robert J Fletterick
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

Review 5.  Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells.

Authors:  Takashi Yazawa; Yoshitaka Imamichi; Kaoru Miyamoto; Akihiro Umezawa; Takanobu Taniguchi
Journal:  World J Stem Cells       Date:  2014-04-26       Impact factor: 5.326

6.  LRH1 enhances cell resistance to chemotherapy by transcriptionally activating MDC1 expression and attenuating DNA damage in human breast cancer.

Authors:  S Wang; Z Zou; X Luo; Y Mi; H Chang; D Xing
Journal:  Oncogene       Date:  2018-03-16       Impact factor: 9.867

7.  Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth.

Authors:  Dinushan C Kaluarachchi; Allison M Momany; Tamara D Busch; Lucas G Gimenez; Cesar Saleme; Viviana Cosentino; Kaare Christensen; John M Dagle; Kelli K Ryckman; Jeffrey C Murray
Journal:  Pediatr Res       Date:  2016-01-13       Impact factor: 3.756

8.  Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis.

Authors:  Wei-An Lai; Yi-Ting Yeh; Ming-Ting Lee; Leang-Shin Wu; Ferng-Chun Ke; Jiuan-Jiuan Hwang
Journal:  J Lipid Res       Date:  2012-11-28       Impact factor: 5.922

9.  Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies.

Authors:  Dimitrios Gkikas; Dimitris Stellas; Alexia Polissidis; Theodora Manolakou; Maroula G Kokotou; George Kokotos; Panagiotis K Politis
Journal:  Proc Natl Acad Sci U S A       Date:  2021-09-28       Impact factor: 11.205

10.  NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.

Authors:  Jérôme Fortin; Vikas Kumar; Xiang Zhou; Ying Wang; Johan Auwerx; Kristina Schoonjans; Ulrich Boehm; Derek Boerboom; Daniel J Bernard
Journal:  PLoS One       Date:  2013-03-11       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.