| Literature DB >> 22266187 |
Hong Chen1, Yi-wei Lin, Ye-qing Mao, Jian Wu, Yun-fu Liu, Xiang-yi Zheng, Li-ping Xie.
Abstract
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of T24 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22266187 DOI： 10.1016/j.canlet.2012.01.027
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679