| Literature DB >> 22266039 |
Joaquín Pastor1, Julen Oyarzabal, Gustavo Saluste, Rosa María Alvarez, Virginia Rivero, Francisco Ramos, Elena Cendón, Carmen Blanco-Aparicio, Nuria Ajenjo, Antonio Cebriá, M I Albarrán, David Cebrián, Ana Corrionero, Jesús Fominaya, Guillermo Montoya, Marco Mazzorana.
Abstract
PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.Entities:
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Year: 2012 PMID： 22266039 DOI： 10.1016/j.bmcl.2011.12.130
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823