Literature DB >> 222654

Platelet aggreation malondialdehyde formation in type IIA hypercholesterolemic patients.

E Tremoli, P Maderna, M Sirtori, C R Sirtori.   

Abstract

Platelet aggregation induced by threshold concentrations of ADP, adrenaline, collagen and Thrombofax was evaluated in 25 type IIA hypercholesterolemic patients in comparison with 15 control subjects. Malondialdehyde (MDA) formation induced by collagen and thrombin was also studied in a subgroup of 8 patients. In the patient group, irreversible platelet aggregation was induced by significantly lower concentrations of both adrenaline (p is less than 0.05) and Thrombofax (p is less than 0.01). MDA formation induced by both aggregating agents was markedly increased (p is less than 0.01) in type IIA hypercholesterolemic patients.

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Year:  1979        PMID： 222654     DOI： 10.1159/000214290

Source DB:  PubMed          Journal:  Haemostasis        ISSN： 0301-0147


  8 in total

1.  Internalization and down-regulation of the prostacyclin receptor in human platelets.

Authors:  S Giovanazzi; M R Accomazzo; O Letari; D Oliva; S Nicosia
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

Review 2.  Platelet activation in normo- and hyperlipoproteinemias.

Authors:  J Nimpf; H Wurm; G M Kostner; T Kenner
Journal:  Basic Res Cardiol       Date:  1986 Sep-Oct       Impact factor: 17.165

3.  Effects of nutrition of disease and life span. II. Vascular disease, serum cholesterol, serum thromboxane, and heart-produced prostacyclin in MRL mice.

Authors:  D A Mark; D R Alonso; K Tack-Goldman; H T Thaler; E Tremoli; B B Weksler; M E Weksler
Journal:  Am J Pathol       Date:  1984-10       Impact factor: 4.307

4.  [Predictor function of hemorheologic parameters with reference to the incidence of manifest circulatory disorders: Concept of the Aachen study].

Authors:  H Kiesewetter; F Jung; K H Ladwig; E Waterloh; P Roebruck; R Schneider; G Kotitschke; R Bach
Journal:  Klin Wochenschr       Date:  1986-07-15

5.  (5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets.

Authors:  A Corsini; G C Folco; R Fumagalli; S Nicosia; M A Noe; D Oliva
Journal:  Br J Pharmacol       Date:  1987-01       Impact factor: 8.739

Review 6.  Dietary prevention of coronary heart disease. Effect of dietary fats on arterial thrombosis.

Authors:  G Hornstra
Journal:  Postgrad Med J       Date:  1980-08       Impact factor: 2.401

7.  Bezafibrate lowers plasma lipids, fibrinogen and platelet aggregability in hypertriglyceridaemia.

Authors:  F Pazzucconi; L Mannucci; L Mussoni; G Gianfranceschi; P Maderna; P Werba; G Franceschini; C R Sirtori; E Tremoli
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 8.  Influences of lipid-modifying agents on hemostasis.

Authors:  C R Sirtori; S Colli
Journal:  Cardiovasc Drugs Ther       Date:  1993-11       Impact factor: 3.727
  8 in total

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