Literature DB >> 22264780

Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.

Beatriz Tavira1, Eliecer Coto, Armando Torres, Carmen Díaz-Corte, Beatriz Díaz-Molina, Francisco Ortega, Manuel Arias, Juan M Díaz, Rafael Selgas, Carlos López-Larrea, Marta Ruiz-Ortega, Alberto Ortiz, Elena González, Josep M Campistol, Victoria Alvarez.   

Abstract

KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22264780     DOI： 10.1016/j.ymgme.2011.12.020

Source DB:  PubMed          Journal:  Mol Genet Metab        ISSN： 1096-7192            Impact factor:   4.797


  16 in total

Review 1.  Dysglycemia after renal transplantation: Definition, pathogenesis, outcomes and implications for management.

Authors:  David Langsford; Karen Dwyer
Journal:  World J Diabetes       Date:  2015-08-25

2.  Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.

Authors:  William S Oetting; Baolin Wu; David P Schladt; Weihua Guan; Jessica van Setten; Brendan J Keating; David Iklé; Rory P Remmel; Casey R Dorr; Roslyn B Mannon; Arthur J Matas; Ajay K Israni; Pamala A Jacobson
Journal:  Transplantation       Date:  2019-06       Impact factor: 4.939

3.  Genetics of new-onset diabetes after transplantation.

Authors:  Jennifer A McCaughan; Amy Jayne McKnight; Alexander P Maxwell
Journal:  J Am Soc Nephrol       Date:  2013-12-05       Impact factor: 10.121

4.  Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation.

Authors:  Zahra Parvizi; Negar Azarpira; Leila Kohan; Masumeh Darai; Kourosh Kazemi; Mohamad Mehdi Parvizi
Journal:  Mol Biol Rep       Date:  2014-07-05       Impact factor: 2.316

Review 5.  From genotype to human β cell phenotype and beyond.

Authors:  Piero Marchetti; Farooq Syed; Mara Suleiman; Marco Bugliani; Lorella Marselli
Journal:  Islets       Date:  2012-09-01       Impact factor: 2.694

Review 6.  Pharmacogenetics of posttransplant diabetes mellitus.

Authors:  P Lancia; T Adam de Beaumais; E Jacqz-Aigrain
Journal:  Pharmacogenomics J       Date:  2017-03-28       Impact factor: 3.550

7.  Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.

Authors:  Jie Chen; Lixin Li; Yunfei An; Junlong Zhang; Yun Liao; Yi Li; Lanlan Wang
Journal:  J Clin Lab Anal       Date:  2017-08-23       Impact factor: 2.352

Review 8.  Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes.

Authors:  Vijay Shivaswamy; Brian Boerner; Jennifer Larsen
Journal:  Endocr Rev       Date:  2015-12-09       Impact factor: 19.871

9.  Proceedings from an international consensus meeting on posttransplantation diabetes mellitus: recommendations and future directions.

Authors:  A Sharif; M Hecking; A P J de Vries; E Porrini; M Hornum; S Rasoul-Rockenschaub; G Berlakovich; M Krebs; A Kautzky-Willer; G Schernthaner; P Marchetti; G Pacini; A Ojo; S Takahara; J L Larsen; K Budde; K Eller; J Pascual; A Jardine; S J L Bakker; T G Valderhaug; T G Jenssen; S Cohney; M D Säemann
Journal:  Am J Transplant       Date:  2014-08-06       Impact factor: 8.086

Review 10.  The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation.

Authors:  Dennis A Hesselink; Rachida Bouamar; Laure Elens; Ron H N van Schaik; Teun van Gelder
Journal:  Clin Pharmacokinet       Date:  2014-02       Impact factor: 6.447
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