BACKGROUND: Results of several studies have suggested a probable etiologic association between Epstein-Barr virus (EBV) and leukemias; therefore, the aim of this study was to investigate the association of EBV in childhood leukemia. METHODS: A direct isothermal amplification method was developed for detection of the latent membrane protein 1 (LMP1) of EBV in the peripheral blood of 80 patients with leukemia (54 had lymphoid leukemia and 26 had myeloid leukemia) and of 20 hematologically healthy control subjects. RESULTS: EBV LMP1 gene transcripts were found in 29 (36.3%) of the 80 patients with leukemia but in none of the healthy controls (P < .0001). Of the 29 EBV(+) cases, 23 (79.3%), 5 (17.3%), and 1 (3.4%) were acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia, respectively. CONCLUSION: EBV LMP1 gene transcriptional activity was observed in a significant proportion of patients with acute lymphoblastic leukemia. EBV infection in patients with lymphoid leukemia may be a factor involved in the high incidence of pediatric leukemia in the Sudan. Copyright Â
BACKGROUND: Results of several studies have suggested a probable etiologic association between Epstein-Barr virus (EBV) and leukemias; therefore, the aim of this study was to investigate the association of EBV in childhood leukemia. METHODS: A direct isothermal amplification method was developed for detection of the latent membrane protein 1 (LMP1) of EBV in the peripheral blood of 80 patients with leukemia (54 had lymphoid leukemia and 26 had myeloid leukemia) and of 20 hematologically healthy control subjects. RESULTS:EBV LMP1 gene transcripts were found in 29 (36.3%) of the 80 patients with leukemia but in none of the healthy controls (P < .0001). Of the 29 EBV(+) cases, 23 (79.3%), 5 (17.3%), and 1 (3.4%) were acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia, respectively. CONCLUSION:EBV LMP1 gene transcriptional activity was observed in a significant proportion of patients with acute lymphoblastic leukemia. EBV infection in patients with lymphoid leukemia may be a factor involved in the high incidence of pediatric leukemia in the Sudan. Copyright Â
Authors: Hussain Gadelkarim Ahmed; Rania Saad Abdul Gader Suliman; Mohammed Siddig Abd El Aziz; Fawaz D Alshammari Journal: Infect Agent Cancer Date: 2015-02-17 Impact factor: 2.965
Authors: Samah Aly Loutfy; Maha A Abo-Shadi; Mohamed Fawzy; Mohamed El-Wakil; Shimaa A Metwally; Manar M Moneer; Nasra F Abdel Fattah; Sara Kassem; Ahmed Elgebaly Journal: Virol J Date: 2017-03-06 Impact factor: 4.099
Authors: Jeremiah Hwee; Christopher Tait; Lillian Sung; Jeffrey C Kwong; Rinku Sutradhar; Jason D Pole Journal: Br J Cancer Date: 2017-10-24 Impact factor: 7.640