| Literature DB >> 22264479 |
Savithri Ramurthy1, Abran Costales, Johanna M Jansen, Barry Levine, Paul A Renhowe, Cynthia M Shafer, Sharadha Subramanian.
Abstract
Compounds belonging to several scaffolds-quinazolines, quinolines and quinoxalines-were designed and synthesized as Raf kinase inhibitors. Scaffolds were assessed for in vitro Braf(V600E) inhibition, and overall kinase selectivity. Pharmacokinetic parameters for one of the scaffolds were also determined.Entities:
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Year: 2011 PMID： 22264479 DOI： 10.1016/j.bmcl.2011.12.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823