| Literature DB >> 22264478 |
Jiwen Jim Liu1, Yingcai Wang, Michael G Johnson, An-Rong Li, Wang Shen, Xuemei Wang, Yongli Su, Matthew Brown, Bettina Van Lengerich, Erika Rickel, Tod Martin, Alison Budelsky, Lisa Seitz, Jay Danao, H Lucy Tang, Tassie Collins, Julio C Medina.
Abstract
Our first generation CRTH2 and DP dual antagonists, represented by AMG 009, are more potent toward the CRTH2 receptor than to the DP receptor. Here we report our efforts in the discovery of CRTH2 and DP dual antagonists with more balanced potencies to both receptors, such as compound 15.Entities:
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Year: 2011 PMID： 22264478 DOI： 10.1016/j.bmcl.2011.12.107
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823