Literature DB >> 2226447

Amino acid sequence and disulfide bridges of an antifungal protein isolated from Aspergillus giganteus.

K Nakaya1, K Omata, I Okahashi, Y Nakamura, H Kolekenbrock, N Ulbrich.   

Abstract

A very basic secreted protein which displays antifungal activity was isolated from the medium of the mold Aspergillus giganteus. The protein consists of 51 amino acid residues whose sequence was determined as Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn- Ile-Cys-Lys-Tyr-Lys-Ala-Gln-Ser-Gly-Lys-Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val- Lys- Lys-Cys-Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser-Tyr-Lys-Gly-Lys-Cys- Tyr-Cys . Disulfide bonds were formed between Cys7-Cys33, Cys14-Cys40, Cys26-Cys28 and Cys49-Cys51. These results suggest that the antifungal protein forms a loop structure and is similar to phospholipase A2.

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Year:  1990        PMID： 2226447     DOI： 10.1111/j.1432-1033.1990.tb19300.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  12 in total

1.  The antifungal protein from Aspergillus giganteus causes membrane permeabilization.

Authors:  T Theis; M Wedde; V Meyer; U Stahl
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

2.  Strategies for Control of Fungal Diseases with Transgenic Plants.

Authors:  BJC. Cornelissen; L. S. Melchers
Journal:  Plant Physiol       Date:  1993-03       Impact factor: 8.340

3.  A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization.

Authors:  Mohamed Hajji; Kemel Jellouli; Noomen Hmidet; Rafik Balti; Alya Sellami-Kamoun; Moncef Nasri
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-04       Impact factor: 3.346

4.  Rust and downy mildew resistance in pearl millet (Pennisetum glaucum) mediated by heterologous expression of the afp gene from Aspergillus giganteus.

Authors:  Maram Girgi; Wendy A Breese; Horst Lörz; Klaus H Oldach
Journal:  Transgenic Res       Date:  2006-06       Impact factor: 2.788

5.  Optimization and partial characterization of intracellular anticandidal protein from Aspergillus giganteus MTCC 8408 using taguchi DOE.

Authors:  Debashis Dutta; Mira Debnath Das
Journal:  Bioengineered       Date:  2017-01-19       Impact factor: 3.269

6.  Characterization of a novel, antifungal, chitin-binding protein from Streptomyces tendae Tü901 that interferes with growth polarity.

Authors:  C Bormann; D Baier; I Hörr; C Raps; J Berger; G Jung; H Schwarz
Journal:  J Bacteriol       Date:  1999-12       Impact factor: 3.490

7.  Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L.

Authors:  M F De Bolle; K Eggermont; R E Duncan; R W Osborn; F R Terras; W F Broekaert
Journal:  Plant Mol Biol       Date:  1995-07       Impact factor: 4.076

8.  Molecular cloning, sequence analysis and expression of the gene encoding an antifungal-protein from Aspergillus giganteus.

Authors:  S Wnendt; N Ulbrich; U Stahl
Journal:  Curr Genet       Date:  1994-06       Impact factor: 3.886

9.  Transgenic rice plants expressing the antifungal AFP protein from Aspergillus giganteus show enhanced resistance to the rice blast fungus Magnaporthe grisea.

Authors:  María Coca; Cristina Bortolotti; Mar Rufat; Gisela Peñas; Ramón Eritja; Didier Tharreau; Alvaro Martinez del Pozo; Joaquima Messeguer; Blanca San Segundo
Journal:  Plant Mol Biol       Date:  2004-01       Impact factor: 4.076

10.  Efficient production and characterization of the novel and highly active antifungal protein AfpB from Penicillium digitatum.

Authors:  Sandra Garrigues; Mónica Gandía; Crina Popa; Attila Borics; Florentine Marx; María Coca; Jose F Marcos; Paloma Manzanares
Journal:  Sci Rep       Date:  2017-11-07       Impact factor: 4.379
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