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Literature DB >> 22264109

Behavioral phenotype of fragile X syndrome in adolescence and adulthood.

Leann E Smith¹, Erin T Barker, Marsha Mailick Seltzer, Leonard Abbeduto, Jan S Greenberg.

Abstract

The present study explored the behavioral profile of individuals with fragile X syndrome during adolescence and adulthood. Individuals with both fragile X syndrome and autism (n = 30) were compared with (a) individuals diagnosed with fragile X syndrome (but not autism; n = 106) and (b) individuals diagnosed with autism (but not fragile X syndrome; n = 135) on measures of autism symptoms, adaptive functioning, behavior problems, and psychological symptoms. Results indicated that individuals dually diagnosed with fragile X syndrome and autism displayed greater communication and social reciprocity impairments than individuals with fragile X syndrome only. Individuals in the dually diagnosed group also exhibited higher levels of repetitive and challenging behaviors than either comparison group, suggesting a unique profile of vulnerability for those diagnosed with both fragile X syndrome and autism.

Entities: Disease Gene Species

Mesh：

Year: 2012 PMID： 22264109 PMCID： PMC3388941 DOI： 10.1352/1944-7558-117.1.1

Source DB: PubMed Journal: Am J Intellect Dev Disabil ISSN： 1944-7558

31 in total

1. Longitudinal changes in cognitive and adaptive behavior scores in children and adolescents with the fragile X mutation or autism.

Authors: Gene S Fisch; Richard J Simensen; R J Schroer
Journal: J Autism Dev Disord Date: 2002-04

2. Psychological well-being and coping in mothers of youths with autism, Down syndrome, or fragile X syndrome.

Authors: Leonard Abbeduto; Marsha Mailick Seltzer; Paul Shattuck; Marty Wyngaarden Krauss; Gael Orsmond; Melissa M Murphy
Journal: Am J Ment Retard Date: 2004-05

3. The behavioral phenotype in fragile X: symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders.

Authors: S J Rogers; D E Wehner; R Hagerman
Journal: J Dev Behav Pediatr Date: 2001-12 Impact factor: 2.225

4. Developmental changes of autistic symptoms.

Authors: Shirley Fecteau; Laurent Mottron; Claude Berthiaume; Jacob A Burack
Journal: Autism Date: 2003-09

5. Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors.

Authors: Walter E Kaufmann; Ranon Cortell; Alice S M Kau; Irena Bukelis; Elaine Tierney; Robert M Gray; Christiane Cox; George T Capone; Pia Stanard
Journal: Am J Med Genet A Date: 2004-09-01 Impact factor: 2.802

6. Linguistic and cognitive functioning and autism symptoms in young children with fragile X syndrome.

Authors: Amy Philofsky; Susan L Hepburn; Athena Hayes; Randi Hagerman; Sally J Rogers
Journal: Am J Ment Retard Date: 2004-05

7. Adaptive behavior in children with fragile X syndrome.

Authors: Deborah D Hatton; Anne C Wheeler; Martie L Skinner; Donald B Bailey; Kelly M Sullivan; Jane E Roberts; Penny Mirrett; Renee D Clark
Journal: Am J Ment Retard Date: 2003-11

8. Autistic-like behaviour profile and psychiatric morbidity in Fragile X Syndrome: a prospective ten-year follow-up study.

Authors: Manga Sabaratnam; Naga Venkatesha Murthy; Anusha Wijeratne; Ann Buckingham; Stewart Payne
Journal: Eur Child Adolesc Psychiatry Date: 2003-08 Impact factor: 4.785

9. The symptoms of autism spectrum disorders in adolescence and adulthood.

Authors: Marsha Mailick Seltzer; Marty Wyngaarden Krauss; Paul T Shattuck; Gael Orsmond; April Swe; Catherine Lord
Journal: J Autism Dev Disord Date: 2003-12

10. Behavioral relationship between autism and fragile x syndrome.

Authors: Jenny L Demark; Maurice A Feldman; Jeanette J A Holden
Journal: Am J Ment Retard Date: 2003-09

49 in total

1. Daily health symptoms of mothers of adolescents and adults with fragile x syndrome and mothers of adolescents and adults with autism spectrum disorder.

Authors: Leann E Smith; Marsha Mailick Seltzer; Jan S Greenberg
Journal: J Autism Dev Disord Date: 2012-09

2. Change in the Behavioral Phenotype of Adolescents and Adults with FXS: Role of the Family Environment.

Authors: Leann E Smith; Jinkuk Hong; Jan S Greenberg; Marsha R Mailick
Journal: J Autism Dev Disord Date: 2016-05

3. Unaffected siblings of adolescents and adults with fragile X syndrome: Effects on maternal well-being.

Authors: Lauren V Usher; Leann S DaWalt; Jan S Greenberg; Marsha R Mailick
Journal: J Fam Psychol Date: 2018-09-13

4. Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome.

Authors: Jordan Ezell; Abigail Hogan; Amanda Fairchild; Kimberly Hills; Jessica Klusek; Leonard Abbeduto; Jane Roberts
Journal: J Autism Dev Disord Date: 2019-03

Review 5. Understanding the pediatric psychiatric phenotype of 22q11.2 deletion syndrome.

Authors: Ania M Fiksinski; Maude Schneider; Clodagh M Murphy; Marco Armando; Stefano Vicari; Jaume M Canyelles; Doron Gothelf; Stephan Eliez; Elemi J Breetvelt; Celso Arango; Jacob A S Vorstman
Journal: Am J Med Genet A Date: 2018-09-08 Impact factor: 2.802

6. Longitudinal trajectories of aberrant behavior in fragile X syndrome.

Authors: Kristin M Hustyi; Scott S Hall; Booil Jo; Amy A Lightbody; Allan L Reiss
Journal: Res Dev Disabil Date: 2014-08-15

7. Executive Functioning Mediates the Effect of Behavioral Problems on Depression in Mothers of Children With Developmental Disabilities.

Authors: Wai Chan; Leann E Smith; Jan S Greenberg; Jinkuk Hong; Marsha R Mailick
Journal: Am J Intellect Dev Disabil Date: 2017-01