Effects of weight cycling on metabolic control in male outpatients with non-insulin-dependent diabetes mellitus.

Examined the effects of weight cycling (i.e., losing and regaining or gaining and relosing body weight) versus weight maintenance on metabolic control in 327 adult, male, outpatient veterans with non-insulin-dependent diabetes mellitus (NIDDM) who were followed over an average of 3.4 years. When compared with weight maintenance, weight cycling, whether defined as a categorical or as a continuous variable, was not found to be associated with deficits in metabolic control or increased need for hypoglycemic medication. Patients who weight cycled had fasting serum glucose and hemoglobin A1c levels comparable to those who remained within 10% of their initial body weights, and these levels of metabolic control were obtained with similar classes and dosages of hypoglycemic medication.