Literature DB >> 22263088

Inoperable stage III non-small cell lung cancer: Current treatment and role of vinorelbine.

Mariano Provencio1, Dolores Isla, Antonio Sánchez, Blanca Cantos.   

Abstract

Most lung cancer patients are diagnosed with a non-resectable disease; and around 40% in advanced stages. Stage III non-small cell lung cancer (NSCLC) is a heterogeneous disease with great variations in its clinical extent which presents a major therapeutic challenge. Although chemo-radiotherapy treatment has become the most widely used, there is currently no consensus on the best standard treatment and the experience of the therapy team plays an important role in the decision taking. We review the treatment of inoperable stage III NSCLC and the role of concomitant vinorelbine in this clinical scenario.

Entities:  

Keywords:  chemo-radiotherapy; chemotherapy; non-small cell lung cancer; stage III; vinorelbine

Year:  2011        PMID: 22263088      PMCID: PMC3256525          DOI: 10.3978/j.issn.2072-1439.2011.01.02

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN: 2072-1439            Impact factor:   2.895


  49 in total

1.  Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors.

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3.  Radiotherapy alone versus combined chemotherapy and radiotherapy in unresectable non-small cell lung carcinoma.

Authors:  T Le Chevalier; R Arriagada; E Quoix; P Ruffie; M Martin; J Y Douillard; M Tarayre; M J Lacombe-Terrier; A Laplanche
Journal:  Lung Cancer       Date:  1994-03       Impact factor: 5.705

Review 4.  Developments in cytotoxic chemotherapy: advances in treatment utilising vinorelbine.

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Journal:  J Clin Oncol       Date:  2007-04-02       Impact factor: 44.544

6.  Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer.

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Review 7.  Concurrent chemoradiotherapy in non-small cell lung cancer.

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Journal:  J Clin Oncol       Date:  2008-05-27       Impact factor: 44.544

9.  Non-small-cell lung cancer in elderly patients: influence of age on vinorelbine oral pharmacokinetics.

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10.  Inoperable non-small cell lung cancer: radiation with or without chemotherapy.

Authors:  K Mattson; L R Holsti; P Holsti; M Jakobsson; M Kajanti; K Liippo; M Mäntylä; S Niitamo-Korhonen; V Nikkanen; E Nordman
Journal:  Eur J Cancer Clin Oncol       Date:  1988-03
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  21 in total

1.  Early Detection of Recurrence in Patients With Locally Advanced Non-Small-Cell Lung Cancer via Circulating Tumor Cell Analysis.

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Journal:  Clin Lung Cancer       Date:  2019-05-04       Impact factor: 4.785

2.  Modern radiotherapy using image guidance for unresectable non-small cell lung cancer can improve outcomes in patients treated with chemoradiation therapy.

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3.  Lung cancer prognosis before and after recurrence in a population-based setting.

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Journal:  J Natl Cancer Inst       Date:  2015-03-23       Impact factor: 13.506

4.  Antitumor activity of nimotuzumab in combination with cisplatin in lung cancer cell line A549 in vitro.

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5.  Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation.

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6.  Thoracic Vertebral Body Irradiation Contributes to Acute Hematologic Toxicity During Chemoradiation Therapy for Non-Small Cell Lung Cancer.

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7.  TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.

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8.  Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma.

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9.  Concurrent chemoradiotherapy with vinorelbine plus split-dose cisplatin may be an option in inoperable stage III non-small cell lung cancer: a single-center experience.

Authors:  Hüseyin Mertsoylu; Fatih Köse; Ahmet Taner Sümbül; Ali Murat Sedef; Özlem Doğan; Ali Ayberk Besen; Cem Parlak; Alper Fındıkçıoğlu; Sadık Muallaoğlu; Ahmet Sezer; Hakan Sakallı; Özgür Özyılkan
Journal:  Med Sci Monit       Date:  2015-03-03

10.  Feasibility, tolerability, and efficacy of the concurrent addition of erlotinib to thoracic radiotherapy in locally advanced unresectable non-small-cell lung cancer: a Phase II trial.

Authors:  Enrique Martínez; Maite Martínez; Mikel Rico; Berta Hernández; Francesc Casas; Nuria Viñolas; Ana Pérez-Casas; Manuel Dómine; Julián Mínguez
Journal:  Onco Targets Ther       Date:  2016-03-01       Impact factor: 4.147

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