BACKGROUND: High levels of serum phosphorus, even within the normal range, have been associated with cardiovascular (CV) morbidity. Low-grade albuminuria (LGA) was demonstrated to be related to increased CV events in various study populations. The present study aimed to investigate the association between serum phosphorus levels and LGA in the general population. METHODS: We examined the individuals who had undergone health inspections. We evaluated the correlation between serum phosphorus and LGA in 8953 participants (mean age, 47.4 years) with estimated glomerular filtration rates (eGFRs)≥60 mL/min/1.73 m2 and urinary albumin-to-creatinine ratios (UACRs)<30 mg/g. Participants who underwent a colonoscopy were excluded. RESULTS: The mean UACR was significantly higher in the uppermost quartile group of serum phosphorus concentrations than in other quartile groups. In the multivariate regression analysis, serum phosphorus remained an independent predictor of increased UACR (B=0.610, P<0.001). Subgroup analyses showed that this association was maintained irrespective of age, gender, presence of hypertension or diabetes, body mass index and eGFR. CONCLUSIONS: In our population-based study, higher serum phosphorus was independently related to LGA in individuals without evidence of renal dysfunction. Further investigations are warranted to clarify the precise mechanism of the association between serum phosphorus and LGA.
BACKGROUND: High levels of serum phosphorus, even within the normal range, have been associated with cardiovascular (CV) morbidity. Low-grade albuminuria (LGA) was demonstrated to be related to increased CV events in various study populations. The present study aimed to investigate the association between serum phosphorus levels and LGA in the general population. METHODS: We examined the individuals who had undergone health inspections. We evaluated the correlation between serum phosphorus and LGA in 8953 participants (mean age, 47.4 years) with estimated glomerular filtration rates (eGFRs)≥60 mL/min/1.73 m2 and urinary albumin-to-creatinine ratios (UACRs)<30 mg/g. Participants who underwent a colonoscopy were excluded. RESULTS: The mean UACR was significantly higher in the uppermost quartile group of serum phosphorus concentrations than in other quartile groups. In the multivariate regression analysis, serum phosphorus remained an independent predictor of increased UACR (B=0.610, P<0.001). Subgroup analyses showed that this association was maintained irrespective of age, gender, presence of hypertension or diabetes, body mass index and eGFR. CONCLUSIONS: In our population-based study, higher serum phosphorus was independently related to LGA in individuals without evidence of renal dysfunction. Further investigations are warranted to clarify the precise mechanism of the association between serum phosphorus and LGA.
Authors: Charles Ginsberg; Alfons J H M Houben; Rakesh Malhotra; Tos T J M Berendschot; Pieter C Dagnelie; Jeroen P Kooman; Caroll A Webers; Coen D A Stehouwer; Joachim H Ix Journal: Clin J Am Soc Nephrol Date: 2019-09-20 Impact factor: 8.237
Authors: Alex Chang; Bryan C Batch; Heather L McGuire; William M Vollmer; Laura P Svetkey; Crystal C Tyson; Anawin Sanguankeo; Cheryl Anderson; Jessica Houston; Lawrence J Appel Journal: Am J Kidney Dis Date: 2013-06-28 Impact factor: 8.860
Authors: Alex R Chang; Mariana Lazo; Lawrence J Appel; Orlando M Gutiérrez; Morgan E Grams Journal: Am J Clin Nutr Date: 2013-11-13 Impact factor: 7.045
Authors: Timothy Ellam; James Fotheringham; Martin E Wilkie; Sheila E Francis; Timothy J A Chico Journal: PLoS One Date: 2014-02-05 Impact factor: 3.240
Authors: Eunjeong Kang; Sehoon Park; Jina Park; Yaerim Kim; Minsu Park; Kwangsoo Kim; Hyo Jeong Kim; Miyeun Han; Jang-Hee Cho; Jung Pyo Lee; Sik Lee; Soo Wan Kim; Sang Min Park; Dong-Wan Chae; Ho Jun Chin; Yong Chul Kim; Yon Su Kim; Insun Choi; Hajeong Lee Journal: Kidney Res Clin Pract Date: 2021-11-05