OBJECTIVE: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. METHODS: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. RESULTS: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). CONCLUSION: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
OBJECTIVE: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. METHODS: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. RESULTS: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). CONCLUSION: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
Authors: Bryce A Mander; Alyssa H Zhu; John R Lindquist; Sylvia Villeneuve; Vikram Rao; Brandon Lu; Jared M Saletin; Sonia Ancoli-Israel; William J Jagust; Matthew P Walker Journal: J Neurosci Date: 2017-10-30 Impact factor: 6.167
Authors: Charles K Davis; Saivenkateshkomal Bathula; Martin Hsu; Kahlilia C Morris-Blanco; Anil K Chokkalla; Soomin Jeong; Jeongwoo Choi; Shruti Subramanian; Jin Soo Park; Zsuzsanna Fabry; Raghu Vemuganti Journal: J Neurosci Date: 2022-07-25 Impact factor: 6.709
Authors: R Mohtasib; J Alghamdi; A Jobeir; A Masawi; N Pedrosa de Barros; T Billiet; H Struyfs; T V Phan; W Van Hecke; A Ribbens Journal: Heliyon Date: 2022-02-02
Authors: Hanne Struyfs; Wim Van Hecke; Jelle Veraart; Jan Sijbers; Sylvie Slaets; Maya De Belder; Laura Wuyts; Benjamin Peters; Kristel Sleegers; Caroline Robberecht; Christine Van Broeckhoven; Frank De Belder; Paul M Parizel; Sebastiaan Engelborghs Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472