OBJECTIVES: This study sought to compare survival of patients with poorly compressible arteries (PCA) to those with a normal ankle-brachial index (ABI) and those with peripheral arterial disease (PAD). BACKGROUND: Limited data are available regarding survival in patients with PCA identified in the clinical setting by noninvasive lower extremity arterial evaluation. METHODS: We conducted a historical cohort study of consecutive patients who underwent outpatient, noninvasive lower extremity arterial evaluation at the Mayo Clinic, Rochester, Minnesota, from January 1998 through December 2007, and who were followed for a mean duration of 5.8 ± 3.1 years. An ABI 1.00 to 1.30 was considered normal, PAD was defined as a resting or post-exercise ABI ≤0.90, and PCA defined as an ABI ≥1.4 and/or an ankle systolic blood pressure >255 mm Hg. Patients were followed for all-cause mortality through September 30, 2009. RESULTS: Of 16,493 individuals (mean age 67.8 ± 13.0 years, 59% male); 29% had normal ABI, 54% had PAD, and 17% had PCA. During follow-up (mean duration 5.8 ± 3.1 years), 4,365 patients (26%) died. The percent alive at the end of the study period was 88%, 70%, and 60% for normal ABI, PAD, and PCA, respectively. After adjustment for age, sex, cardiovascular risk factors, comorbid conditions, and medication use, the hazard ratios (95% confidence intervals) of death associated with PCA were 2.0 (1.8 to 2.2) and 1.3 (1.2 to 1.4) compared with the normal ABI and PAD groups, respectively. CONCLUSIONS: Patients identified by noninvasive vascular testing to have poorly compressible leg arteries have poor survival, worse than those with a normal ABI or those with PAD.
OBJECTIVES: This study sought to compare survival of patients with poorly compressible arteries (PCA) to those with a normal ankle-brachial index (ABI) and those with peripheral arterial disease (PAD). BACKGROUND: Limited data are available regarding survival in patients with PCA identified in the clinical setting by noninvasive lower extremity arterial evaluation. METHODS: We conducted a historical cohort study of consecutive patients who underwent outpatient, noninvasive lower extremity arterial evaluation at the Mayo Clinic, Rochester, Minnesota, from January 1998 through December 2007, and who were followed for a mean duration of 5.8 ± 3.1 years. An ABI 1.00 to 1.30 was considered normal, PAD was defined as a resting or post-exercise ABI ≤0.90, and PCA defined as an ABI ≥1.4 and/or an ankle systolic blood pressure >255 mm Hg. Patients were followed for all-cause mortality through September 30, 2009. RESULTS: Of 16,493 individuals (mean age 67.8 ± 13.0 years, 59% male); 29% had normal ABI, 54% had PAD, and 17% had PCA. During follow-up (mean duration 5.8 ± 3.1 years), 4,365 patients (26%) died. The percent alive at the end of the study period was 88%, 70%, and 60% for normal ABI, PAD, and PCA, respectively. After adjustment for age, sex, cardiovascular risk factors, comorbid conditions, and medication use, the hazard ratios (95% confidence intervals) of death associated with PCA were 2.0 (1.8 to 2.2) and 1.3 (1.2 to 1.4) compared with the normal ABI and PAD groups, respectively. CONCLUSIONS:Patients identified by noninvasive vascular testing to have poorly compressible leg arteries have poor survival, worse than those with a normal ABI or those with PAD.
Authors: M H Criqui; R D Langer; A Fronek; H S Feigelson; M R Klauber; T J McCann; D Browner Journal: N Engl J Med Date: 1992-02-06 Impact factor: 91.245
Authors: Michael H Criqui; Robyn L McClelland; Mary M McDermott; Matthew A Allison; Roger S Blumenthal; Victor Aboyans; Joachim H Ix; Gregory L Burke; Kaing Liu; Steven Shea Journal: J Am Coll Cardiol Date: 2010-10-26 Impact factor: 24.094
Authors: Victor Aboyans; Elena Ho; Julie O Denenberg; Lindsey A Ho; Loki Natarajan; Michael H Criqui Journal: J Vasc Surg Date: 2008-08-09 Impact factor: 4.268
Authors: Christine Espinola-Klein; Hans J Rupprecht; Christoph Bickel; Karl Lackner; Savvas Savvidis; Claudia M Messow; Thomas Munzel; Stefan Blankenberg Journal: Circulation Date: 2008-08-12 Impact factor: 29.690
Authors: F Gerry R Fowkes; Victor Aboyans; Freya J I Fowkes; Mary M McDermott; Uchechukwu K A Sampson; Michael H Criqui Journal: Nat Rev Cardiol Date: 2016-11-17 Impact factor: 32.419
Authors: Kristian Barlinn; Stanislava Kolieskova; Reza Bavarsad Shahripour; Jessica Kepplinger; Amelia K Boehme; Timo Siepmann; Volker Puetz; Ulf Bodechtel; William D Jordan; Andrei V Alexandrov Journal: J Stroke Cerebrovasc Dis Date: 2014-11-06 Impact factor: 2.136
Authors: J Dawn Abbott; Manuel S Lombardero; Gregory W Barsness; Ivan Pena-Sing; L Virginia Buitrón; Premranjan Singh; Gail Woodhead; Jean-Claude Tardif; Sheryl F Kelsey Journal: Am Heart J Date: 2012-10 Impact factor: 4.749
Authors: Adelaide M Arruda-Olson; Homam Moussa Pacha; Naveed Afzal; Sara Abram; Bradley R Lewis; Iyad Isseh; Raad Haddad; Christopher G Scott; Kent Bailey; Hongfang Liu; Thom W Rooke; Iftikhar J Kullo Journal: Vasc Med Date: 2017-10-25 Impact factor: 3.239
Authors: Sanjay Misra; Mehdi H Shishehbor; Edwin A Takahashi; Herbert D Aronow; Luke P Brewster; Matthew C Bunte; Esther S H Kim; Jonathan R Lindner; Kathleen Rich Journal: Circulation Date: 2019-08-12 Impact factor: 29.690
Authors: John J Squiers; Jeffrey E Thatcher; David S Bastawros; Andrew J Applewhite; Ronald D Baxter; Faliu Yi; Peiran Quan; Shuai Yu; J Michael DiMaio; Dennis R Gable Journal: J Vasc Surg Date: 2021-07-24 Impact factor: 4.268
Authors: Pranav S Garimella; Joachim H Ix; Ronit Katz; Michael G Shlipak; Michael H Criqui; David S Siscovick; Holly Kramer; Christopher T Sibley; Mark J Sarnak Journal: Am J Kidney Dis Date: 2014-07-03 Impact factor: 8.860